Acute effects of oral mesna administration on the full amino acid profile and 3-methylhistidine: secondary results from the CYLOB dose-finding study

Plasma total cysteine (tCys) is strongly associated with fat mass in humans. Mesna lowers plasma tCys in a dose-dependent manner, but it is not known whether it interferes with metabolism of other amino acids or protein. In this Phase-1 study, we show that a single dose of mesna administered at 400,...

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Vydáno v:	Amino acids Ročník 56; číslo 1; s. 39
Hlavní autoři:	Olsen, Thomas, Elshorbagy, Amany, Stolt, Emma, Åsberg, Anders, Zaré, Hasse K., Bastani, Nasser E., Refsum, Helga, Retterstøl, Kjetil, Vinknes, Kathrine J.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Vienna Springer Vienna 06.06.2024 Springer Nature B.V Springer
Témata:	3-methylhistidine Acute effects Administration, Oral Adult amino acid composition Amino acid profile Amino acids Amino Acids - blood Analytical Chemistry Biochemical Engineering Biochemistry Biomedical and Life Sciences Body composition Body fat Brief Report cysteine Cysteine - chemistry dose response Dose-Response Relationship, Drug Drug dosages Female Humans Life Sciences Male Medicine Mesna Metabolism Methylhistidines Middle Aged Musculoskeletal system Neurobiology Obesity Overweight Plasma Protein synthesis Protein turnover Proteins Proteomics Total cysteine Urine Valine Weight control Obesity Mesna Total cysteine Amino acid profile 3-methylhistidine Overweight
ISSN:	1438-2199, 0939-4451, 1438-2199
On-line přístup:	Získat plný text
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Shrnutí:	Plasma total cysteine (tCys) is strongly associated with fat mass in humans. Mesna lowers plasma tCys in a dose-dependent manner, but it is not known whether it interferes with metabolism of other amino acids or protein. In this Phase-1 study, we show that a single dose of mesna administered at 400, 800, 1200 or 1600 mg to 6–7 individuals per dose only slightly affects amino acid profiles, with increases in plasma valine across dose levels. There were no effects of mesna on 3-methylhistidine, a marker of protein breakdown.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 Communicated by D. Tsikas.
ISSN:	1438-2199 0939-4451 1438-2199
DOI:	10.1007/s00726-024-03398-2