Acute effects of oral mesna administration on the full amino acid profile and 3-methylhistidine: secondary results from the CYLOB dose-finding study

Plasma total cysteine (tCys) is strongly associated with fat mass in humans. Mesna lowers plasma tCys in a dose-dependent manner, but it is not known whether it interferes with metabolism of other amino acids or protein. In this Phase-1 study, we show that a single dose of mesna administered at 400,...

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Bibliographic Details
Published in:Amino acids Vol. 56; no. 1; p. 39
Main Authors: Olsen, Thomas, Elshorbagy, Amany, Stolt, Emma, Åsberg, Anders, Zaré, Hasse K., Bastani, Nasser E., Refsum, Helga, Retterstøl, Kjetil, Vinknes, Kathrine J.
Format: Journal Article
Language:English
Published: Vienna Springer Vienna 06.06.2024
Springer Nature B.V
Springer
Subjects:
3-methylhistidine
Acute effects
Administration, Oral
Adult
amino acid composition
Amino acid profile
Amino acids
Amino Acids - blood
Analytical Chemistry
Biochemical Engineering
Biochemistry
Biomedical and Life Sciences
Body composition
Body fat
Brief Report
cysteine
Cysteine - chemistry
dose response
Dose-Response Relationship, Drug
Drug dosages
Female
Humans
Life Sciences
Male
Medicine
Mesna
Metabolism
Methylhistidines
Middle Aged
Musculoskeletal system
Neurobiology
Obesity
Overweight
Plasma
Protein synthesis
Protein turnover
Proteins
Proteomics
Total cysteine
Urine
Valine
Weight control
Obesity
Mesna
Total cysteine
Amino acid profile
3-methylhistidine
Overweight
ISSN:1438-2199, 0939-4451, 1438-2199
Online Access:Get full text
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Summary:Plasma total cysteine (tCys) is strongly associated with fat mass in humans. Mesna lowers plasma tCys in a dose-dependent manner, but it is not known whether it interferes with metabolism of other amino acids or protein. In this Phase-1 study, we show that a single dose of mesna administered at 400, 800, 1200 or 1600 mg to 6–7 individuals per dose only slightly affects amino acid profiles, with increases in plasma valine across dose levels. There were no effects of mesna on 3-methylhistidine, a marker of protein breakdown.
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Communicated by D. Tsikas.
ISSN:1438-2199
0939-4451
1438-2199
DOI:10.1007/s00726-024-03398-2