G-quadruplex Structures Contribute to Differential Radiosensitivity of the Human Genome

DNA, the fundamental unit of human cell, generally exists in Watson-Crick base-paired B-DNA form. Often, DNA folds into non-B forms, such as four-stranded G-quadruplexes. It is generally believed that ionizing radiation (IR) induces DNA strand-breaks in a random manner. Here, we show that regions of...

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Veröffentlicht in:	iScience Jg. 21; S. 288 - 307
Hauptverfasser:	Kumari, Nitu, Vartak, Supriya V., Dahal, Sumedha, Kumari, Susmita, Desai, Sagar S., Gopalakrishnan, Vidya, Choudhary, Bibha, Raghavan, Sathees C.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 22.11.2019 Elsevier
Schlagworte:	Biochemistry Biological Sciences Cell Biology Molecular Biology Biological Sciences Biochemistry Molecular Biology Cell Biology
ISSN:	2589-0042, 2589-0042
Online-Zugang:	Volltext
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