Nutrition and its role in epigenetic inheritance of obesity and diabetes across generations

Nutritional constraints including not only caloric restriction or protein deficiency, but also energy-dense diets affect metabolic health and frequently lead to obesity and insulin resistance, as well as glucose intolerance and type 2 diabetes. The effects of these environmental factors are often me...

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Veröffentlicht in:	Mammalian genome Jg. 31; H. 5-6; S. 119 - 133
Hauptverfasser:	Kaspar, Daniela, Hastreiter, Sieglinde, Irmler, Martin, Hrabé de Angelis, Martin, Beckers, Johannes
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Springer US 01.06.2020 Springer Nature B.V
Schlagworte:	Animal Genetics and Genomics animal models Animals Biomedical and Life Sciences Cell Biology Cytosine Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Dietary restrictions DNA Methylation Embryogenesis Embryonic Development - genetics Endocrine Disruptors - administration & dosage Environmental factors Epigenetics Female Gametes gene expression regulation Gene-Environment Interaction genomics germ cells glucose Glucose Intolerance - genetics Glucose Intolerance - metabolism Glucose Intolerance - pathology Glucose tolerance Heredity Histones Histones - genetics Histones - metabolism Human Genetics Humans Inheritance Patterns Insulin insulin resistance Insulin Resistance - genetics Intolerance Life Sciences low calorie diet Male Malnutrition - complications Malnutrition - genetics Malnutrition - metabolism Malnutrition - pathology mammals Metabolism noninsulin-dependent diabetes mellitus Obesity Obesity - etiology Obesity - genetics Obesity - metabolism Obesity - pathology Overnutrition - complications Overnutrition - genetics Overnutrition - metabolism Overnutrition - pathology protein deficiencies Protein deficiency RNA, Messenger - genetics RNA, Messenger - metabolism
ISSN:	0938-8990, 1432-1777, 1432-1777
Online-Zugang:	Volltext
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