Molecular detection of monkeypox and related viruses: challenges and opportunities

The recent widespread emergence of monkeypox (mpox), a rare and endemic zoonotic disease by monkeypox virus (MPXV), has made global headlines. While transmissibility ( R 0 ≈ 0.58) and fatality rate (0–3%) are low, as it causes prolonged morbidity, the World Health Organization has declared monkeypox...

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Vydáno v:	Virus genes Ročník 59; číslo 3; s. 343 - 350
Hlavní autoři:	Ghate, Sudeep D., Suravajhala, Prashanth, Patil, Prakash, Vangala, Rajani Kanth, Shetty, Praveenkumar, Rao, R. Shyama Prasad
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Springer US 01.06.2023 Springer Nature B.V
Témata:	Antibodies Antigens bioinformatics Biomedical and Life Sciences Biomedicine complement Coronaviruses COVID-19 vaccines disease control Disease management DNA, Viral - genetics Epidemics Fatalities Genomes Hemagglutinins Humans Immunization Infectious diseases Medical Microbiology Monkeypox virus Monkeypox virus - genetics Morbidity mortality Mpox Mpox (monkeypox) - diagnosis Mpox (monkeypox) - pathology Peptides Plant Sciences Polymerase Chain Reaction Proteins Proteomics Public Health Review Paper Reviews Scientific imaging Smallpox tumor necrosis factor receptors Tumor necrosis factor-TNF Virology Viruses World Health Organization Zoonoses Molecular evolution Diagnostics Epidemiology and public health Orthopoxvirus Viral genome surveillance Emerging infectious diseases
ISSN:	0920-8569, 1572-994X, 1572-994X
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Shrnutí:	The recent widespread emergence of monkeypox (mpox), a rare and endemic zoonotic disease by monkeypox virus (MPXV), has made global headlines. While transmissibility ( R 0 ≈ 0.58) and fatality rate (0–3%) are low, as it causes prolonged morbidity, the World Health Organization has declared monkeypox as a public health emergency of international concern. Thus, effective containment and disease management require quick and efficient detection of MPXV. In this bioinformatic overview, we summarize the numerous molecular tests available for MPXV, and discuss the diversity of genes and primers used in the polymerase chain reaction-based detection. Over 90 primer/probe sets are used for the detection of poxviruses. While hemagglutinin and A-type inclusion protein are the most common target genes, tumor necrosis factor receptor and complement binding protein genes are frequently used for distinguishing Clade I and Clade II of MPXV. Problems and possibilities in the detection of MPXV have been discussed.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 Edited by Joachim J. Bugert.
ISSN:	0920-8569 1572-994X 1572-994X
DOI:	10.1007/s11262-023-01975-3