Heat shock protein 60 levels in tissue and circulating exosomes in human large bowel cancer before and after ablative surgery

BACKGROUND Heat shock protein 60 (Hsp60) is a chaperonin involved in tumorigenesis, but its participation in tumor development and progression is not well understood and its value as a tumor biomarker has not been fully elucidated. In the current study, the authors presented evidence supporting the...

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Bibliographic Details
Published in:	Cancer Vol. 121; no. 18; pp. 3230 - 3239
Main Authors:	Campanella, Claudia, Rappa, Francesca, Sciumè, Carmelo, Marino Gammazza, Antonella, Barone, Rosario, Bucchieri, Fabio, David, Sabrina, Curcurù, Giuseppe, Caruso Bavisotto, Celeste, Pitruzzella, Alessandro, Geraci, Girolamo, Modica, Giuseppe, Farina, Felicia, Zummo, Giovanni, Fais, Stefano, Conway de Macario, Everly, Macario, Alberto J.L., Cappello, Francesco
Format:	Journal Article
Language:	English
Published:	United States 15.09.2015
Subjects:	Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenocarcinoma - surgery Aged Aged, 80 and over Biomarkers, Tumor - analysis Blotting, Western Chaperonin 60 - analysis Chaperonin 60 - metabolism colon adenocarcinoma Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colonic Neoplasms - surgery Enzyme-Linked Immunosorbent Assay exosomes Exosomes - metabolism Female heat shock protein 60 (Hsp60) Humans Immunohistochemistry macrophages Male Middle Aged Mitochondrial Proteins - analysis Mitochondrial Proteins - metabolism natural killer cells plasma cell membrane Real-Time Polymerase Chain Reaction theranostics heat shock protein 60 (Hsp60) plasma cell membrane natural killer cells macrophages colon adenocarcinoma exosomes theranostics
ISSN:	0008-543X, 1097-0142
Online Access:	Get full text
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