APF and dentifrice effect on root dentin demineralization and biofilm

Because dentin is more caries-susceptible than enamel, its demineralization may be more influenced by additional fluoride (F). We hypothesized that a combination of professional F, applied as acidulated phosphate F (APF), and use of 1100-ppm-F dentifrice would provide additional protection for denti...

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Bibliographic Details
Published in:Journal of dental research Vol. 90; no. 1; p. 77
Main Authors: Vale, G C, Tabchoury, C P M, Del Bel Cury, A A, Tenuta, L M A, ten Cate, J M, Cury, J A
Format: Journal Article
Language:English
Published: United States 01.01.2011
Subjects:
Acidulated Phosphate Fluoride - administration & dosage
Acidulated Phosphate Fluoride - therapeutic use
Adult
Apatites - analysis
Biofilms - drug effects
Calcium Fluoride - analysis
Cariogenic Agents - adverse effects
Cariostatic Agents - administration & dosage
Cariostatic Agents - therapeutic use
Cross-Over Studies
Dental Plaque - microbiology
Dentifrices - administration & dosage
Dentifrices - therapeutic use
Dentin - drug effects
Dentin - microbiology
Double-Blind Method
Drug Combinations
Fluorides - administration & dosage
Fluorides - therapeutic use
Gels
Hardness
Humans
Microradiography
Placebos
Sucrose - adverse effects
Time Factors
Tooth Demineralization - prevention & control
Tooth Root - drug effects
Tooth Root - microbiology
Young Adult
ISSN:1544-0591, 1544-0591
Online Access:Get more information
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Summary:Because dentin is more caries-susceptible than enamel, its demineralization may be more influenced by additional fluoride (F). We hypothesized that a combination of professional F, applied as acidulated phosphate F (APF), and use of 1100-ppm-F dentifrice would provide additional protection for dentin compared with 1100-ppm-F alone. Twelve adult volunteers wore palatal appliances containing root dentin slabs, which were subjected, during 4 experimental phases of 7 days each, to biofilm accumulation and sucrose exposure 8x/day. The volunteers were randomly assigned to the following treatments: placebo dentifrice (PD), 1100-ppm-F dentifrice (FD), APF + PD, and APF+FD. APF gel (1.23% F) was applied to the slabs once at the beginning of the experimental phase, and the dentifrices were used 3x/day. APF and FD increased F concentration in biofilm fluid and reduced root dentin demineralization, presenting an additive effect. Analysis of the data suggests that the combination of APF gel application and daily regular use of 1100-ppm-F dentifrice may provide additional protection against root caries compared with the dentifrice alone.
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ISSN:1544-0591
1544-0591
DOI:10.1177/0022034510383428