Foxl2 is required for commitment to ovary differentiation

Genetic control of female sex differentiation from a bipotential gonad in mammals is poorly understood. We find that mouse XX gonads lacking the forkhead transcription factor Foxl2 form meiotic prophase oocytes, but then activate the genetic program for somatic testis determination. Pivotal Foxl2 ac...

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Vydané v:	Human molecular genetics Ročník 14; číslo 14; s. 2053
Hlavní autori:	Ottolenghi, Chris, Omari, Shakib, Garcia-Ortiz, J Elias, Uda, Manuela, Crisponi, Laura, Forabosco, Antonino, Pilia, Giuseppe, Schlessinger, David
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 15.07.2005
Predmet:	Animals Female Forkhead Box Protein L2 Forkhead Transcription Factors - genetics Immunohistochemistry Mice Microscopy, Electron Ovary - embryology Ovary - physiology Ovary - ultrastructure Sex Differentiation - genetics
ISSN:	0964-6906
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