Foxl2 is required for commitment to ovary differentiation

Genetic control of female sex differentiation from a bipotential gonad in mammals is poorly understood. We find that mouse XX gonads lacking the forkhead transcription factor Foxl2 form meiotic prophase oocytes, but then activate the genetic program for somatic testis determination. Pivotal Foxl2 ac...

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Bibliographic Details
Published in:Human molecular genetics Vol. 14; no. 14; p. 2053
Main Authors: Ottolenghi, Chris, Omari, Shakib, Garcia-Ortiz, J Elias, Uda, Manuela, Crisponi, Laura, Forabosco, Antonino, Pilia, Giuseppe, Schlessinger, David
Format: Journal Article
Language:English
Published: England 15.07.2005
Subjects:
Animals
Female
Forkhead Box Protein L2
Forkhead Transcription Factors - genetics
Immunohistochemistry
Mice
Microscopy, Electron
Ovary - embryology
Ovary - physiology
Ovary - ultrastructure
Sex Differentiation - genetics
ISSN:0964-6906
Online Access:Get more information
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Summary:Genetic control of female sex differentiation from a bipotential gonad in mammals is poorly understood. We find that mouse XX gonads lacking the forkhead transcription factor Foxl2 form meiotic prophase oocytes, but then activate the genetic program for somatic testis determination. Pivotal Foxl2 action thus represses the male gene pathway at several stages of female gonadal differentiation. This suggests the possible continued involvement of sex-determining genes in maintaining ovarian function throughout female reproductive life.
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ISSN:0964-6906
DOI:10.1093/hmg/ddi210