Foxl2 is required for commitment to ovary differentiation

Genetic control of female sex differentiation from a bipotential gonad in mammals is poorly understood. We find that mouse XX gonads lacking the forkhead transcription factor Foxl2 form meiotic prophase oocytes, but then activate the genetic program for somatic testis determination. Pivotal Foxl2 ac...

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Bibliographic Details

Published in:	Human molecular genetics Vol. 14; no. 14; p. 2053
Main Authors:	Ottolenghi, Chris, Omari, Shakib, Garcia-Ortiz, J Elias, Uda, Manuela, Crisponi, Laura, Forabosco, Antonino, Pilia, Giuseppe, Schlessinger, David
Format:	Journal Article
Language:	English
Published:	England 15.07.2005
Subjects:	Animals Female Forkhead Box Protein L2 Forkhead Transcription Factors - genetics Immunohistochemistry Mice Microscopy, Electron Ovary - embryology Ovary - physiology Ovary - ultrastructure Sex Differentiation - genetics
ISSN:	0964-6906
Online Access:	Get more information
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