Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment

In solid tumor oncology, circulating tumor DNA (ctDNA) is poised to transform care through accurate assessment of minimal residual disease (MRD) and therapeutic response monitoring. To overcome the sparsity of ctDNA fragments in low tumor fraction (TF) settings and increase MRD sensitivity, we previ...

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Bibliographic Details
Published in:	Nature medicine Vol. 30; no. 6; pp. 1655 - 1666
Main Authors:	Widman, Adam J., Shah, Minita, Frydendahl, Amanda, Halmos, Daniel, Khamnei, Cole C., Øgaard, Nadia, Rajagopalan, Srinivas, Arora, Anushri, Deshpande, Aditya, Hooper, William F., Quentin, Jean, Bass, Jake, Zhang, Mingxuan, Langanay, Theophile, Andersen, Laura, Steinsnyder, Zoe, Liao, Will, Rasmussen, Mads Heilskov, Henriksen, Tenna Vesterman, Jensen, Sarah Østrup, Nors, Jesper, Therkildsen, Christina, Sotelo, Jesus, Brand, Ryan, Schiffman, Joshua S., Shah, Ronak H., Cheng, Alexandre Pellan, Maher, Colleen, Spain, Lavinia, Krause, Kate, Frederick, Dennie T., den Brok, Wendie, Lohrisch, Caroline, Shenkier, Tamara, Simmons, Christine, Villa, Diego, Mungall, Andrew J., Moore, Richard, Zaikova, Elena, Cerda, Viviana, Kong, Esther, Lai, Daniel, Malbari, Murtaza S., Marton, Melissa, Manaa, Dina, Winterkorn, Lara, Gelmon, Karen, Callahan, Margaret K., Boland, Genevieve, Potenski, Catherine, Wolchok, Jedd D., Saxena, Ashish, Turajlic, Samra, Imielinski, Marcin, Berger, Michael F., Aparicio, Sam, Altorki, Nasser K., Postow, Michael A., Robine, Nicolas, Andersen, Claus Lindbjerg, Landau, Dan A.
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.06.2024 Nature Publishing Group
Subjects:	631/208/69 692/699/67 Aneuploidy Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Biomedical and Life Sciences Biomedicine Cancer Research Circulating Tumor DNA - blood Circulating Tumor DNA - genetics Colorectal cancer Colorectal Neoplasms - blood Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Deep learning Deoxyribonucleic acid DNA DNA Copy Number Variations Enrichment Gene sequencing Genomes Humans Immunotherapy Infectious Diseases Learning algorithms Lung cancer Lung Neoplasms - blood Lung Neoplasms - genetics Lung Neoplasms - pathology Machine Learning Melanoma Metabolic Diseases Minimal residual disease Molecular Medicine Monitoring Neoplasm, Residual - genetics Neoplasms - blood Neoplasms - genetics Neoplasms - pathology Neoplasms - therapy Neurosciences Nucleotides Polymorphism, Single Nucleotide Solid tumors Telemedicine Tumor Burden Tumors Whole Genome Sequencing
ISSN:	1078-8956, 1546-170X, 1546-170X
Online Access:	Get full text
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