Neoplasia and intraocular inflammation: From masquerade syndromes to immunotherapy-induced uveitis

Masquerade syndromes represent a large set of ophthalmological entities that mimic inflammatory conditions. Any delay in their diagnosis may be correlated with systemic dissemination or worsening of the causal disease and, therefore, with poor prognosis. One of the disadvantages of the new potent tr...

Full description

Saved in:
Bibliographic Details
Published in:Progress in retinal and eye research Vol. 72; p. 100761
Main Authors: Touhami, Sara, Audo, Isabelle, Terrada, Céline, Gaudric, Alain, LeHoang, Phuc, Touitou, Valérie, Bodaghi, Bahram
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01.09.2019
Subjects:
Amyloidosis
Cancer associated retinopathy
Diagnosis, Differential
Humans
Immunotherapy - adverse effects
Inflammation - diagnosis
Leukemia
Lymphoma
Lymphoma - diagnosis
Lymphoma - therapy
Masquerade syndromes
Melanoma associated retinopathy
Paraneoplastic Syndromes - diagnosis
Paraneoplastic Syndromes - therapy
Retinal Neoplasms - diagnosis
Retinal Neoplasms - therapy
Retinoblastoma
Uveitis - chemically induced
ALL
OCT
CLL
PS
SRD
ICG-A
Leukemia
CNS
CNV
IrAE
PCNSL
TTR
AEPVM
Melanoma associated retinopathy
CTLA-4
AML
CML
PVRL
FAF
Lymphoma
ARB
FTA
MEK
RCD
VKH
PIOL
BDUMP
CAR
ATL
MEKAR
Amyloidosis
IRD
ERG
FA
Retinoblastoma
PD-1
Masquerade syndromes
Cancer associated retinopathy
MAR
ISSN:1350-9462, 1873-1635, 1873-1635
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Masquerade syndromes represent a large set of ophthalmological entities that mimic inflammatory conditions. Any delay in their diagnosis may be correlated with systemic dissemination or worsening of the causal disease and, therefore, with poor prognosis. One of the disadvantages of the new potent treatments of uveitis is the delay that they can induce in the diagnosis of neoplastic intraocular infiltrations. Thorough and careful clinical examination of all patients referred for uveitis, especially when they are Caucasian, over 50 years of age, and with posterior segment involvement, is of paramount importance in this context. Ancillary investigations and often-invasive histo-pathologic evaluation of tissue specimens or ocular fluids are regularly required in these situations. The most common masquerade syndrome is primary vitreoretinal lymphoma (PVRL). New molecular diagnostic tools may be helpful in challenging cases lacking cytological confirmation. Therapeutic strategies targeting tumoral cells in the eye and also in the central nervous system can improve the life expectancy of affected patients. In this review, we discuss diagnostic strategies and current therapies in PVRL and provide an overview of other conditions that can mimic primary ocular inflammation, especially in the field of oncology and its new therapeutic armamentarium.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1350-9462
1873-1635
1873-1635
DOI:10.1016/j.preteyeres.2019.05.002