Neoplasia and intraocular inflammation: From masquerade syndromes to immunotherapy-induced uveitis

Masquerade syndromes represent a large set of ophthalmological entities that mimic inflammatory conditions. Any delay in their diagnosis may be correlated with systemic dissemination or worsening of the causal disease and, therefore, with poor prognosis. One of the disadvantages of the new potent tr...

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Vydáno v:	Progress in retinal and eye research Ročník 72; s. 100761
Hlavní autoři:	Touhami, Sara, Audo, Isabelle, Terrada, Céline, Gaudric, Alain, LeHoang, Phuc, Touitou, Valérie, Bodaghi, Bahram
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Elsevier Ltd 01.09.2019
Témata:	Amyloidosis Cancer associated retinopathy Diagnosis, Differential Humans Immunotherapy - adverse effects Inflammation - diagnosis Leukemia Lymphoma Lymphoma - diagnosis Lymphoma - therapy Masquerade syndromes Melanoma associated retinopathy Paraneoplastic Syndromes - diagnosis Paraneoplastic Syndromes - therapy Retinal Neoplasms - diagnosis Retinal Neoplasms - therapy Retinoblastoma Uveitis - chemically induced ALL OCT CLL PS SRD ICG-A Leukemia CNS CNV IrAE PCNSL TTR AEPVM Melanoma associated retinopathy CTLA-4 AML CML PVRL FAF Lymphoma ARB FTA MEK RCD VKH PIOL BDUMP CAR ATL MEKAR Amyloidosis IRD ERG FA Retinoblastoma PD-1 Masquerade syndromes Cancer associated retinopathy MAR
ISSN:	1350-9462, 1873-1635, 1873-1635
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Popis
Shrnutí:	Masquerade syndromes represent a large set of ophthalmological entities that mimic inflammatory conditions. Any delay in their diagnosis may be correlated with systemic dissemination or worsening of the causal disease and, therefore, with poor prognosis. One of the disadvantages of the new potent treatments of uveitis is the delay that they can induce in the diagnosis of neoplastic intraocular infiltrations. Thorough and careful clinical examination of all patients referred for uveitis, especially when they are Caucasian, over 50 years of age, and with posterior segment involvement, is of paramount importance in this context. Ancillary investigations and often-invasive histo-pathologic evaluation of tissue specimens or ocular fluids are regularly required in these situations. The most common masquerade syndrome is primary vitreoretinal lymphoma (PVRL). New molecular diagnostic tools may be helpful in challenging cases lacking cytological confirmation. Therapeutic strategies targeting tumoral cells in the eye and also in the central nervous system can improve the life expectancy of affected patients. In this review, we discuss diagnostic strategies and current therapies in PVRL and provide an overview of other conditions that can mimic primary ocular inflammation, especially in the field of oncology and its new therapeutic armamentarium.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	1350-9462 1873-1635 1873-1635
DOI:	10.1016/j.preteyeres.2019.05.002