FoxA2 involvement in suppression of protein C, an outcome predictor in experimental sepsis

Low levels of protein C (PC) predict outcome as early as 10 h after insult in a rat polymicrobial sepsis model and were associated with suppression of PC mRNA, upstream transcription factor FoxA2, and cofactor hepatocyte nuclear factor 6 (HNF6). Small interfering RNA suppression of FoxA2 in isolated...

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Veröffentlicht in:	Clinical and vaccine immunology Jg. 13; H. 3; S. 426
Hauptverfasser:	Berg, David T, Gerlitz, Bruce, Sharma, Ganesh R, Richardson, Mark A, Stephens, Eddie J, Grubbs, Renee L, Holmes, Kimberly C, Fynboe, Kelly, Montani, Dominick, Cramer, Martin S, Engle, Steven D, Jakubowski, Joseph A, Heuer, Josef G, Grinnell, Brian W
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.03.2006
Schlagworte:	Acute Disease Animals Base Sequence Biomarkers Cecum Disease Models, Animal Female Hepatocyte Nuclear Factor 3-beta - antagonists & inhibitors Hepatocyte Nuclear Factor 3-beta - genetics Hepatocyte Nuclear Factor 3-beta - physiology Ligation Molecular Sequence Data Predictive Value of Tests Prognosis Protein C - antagonists & inhibitors Protein C - biosynthesis Protein C - genetics Protein C - physiology Punctures Rats Rats, Sprague-Dawley RNA, Messenger - antagonists & inhibitors RNA, Messenger - biosynthesis RNA, Small Interfering - pharmacology Sepsis - diagnosis Sepsis - metabolism Sepsis - mortality
ISSN:	1556-6811
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