FoxA2 involvement in suppression of protein C, an outcome predictor in experimental sepsis

Low levels of protein C (PC) predict outcome as early as 10 h after insult in a rat polymicrobial sepsis model and were associated with suppression of PC mRNA, upstream transcription factor FoxA2, and cofactor hepatocyte nuclear factor 6 (HNF6). Small interfering RNA suppression of FoxA2 in isolated...

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Bibliographic Details
Published in:Clinical and vaccine immunology Vol. 13; no. 3; p. 426
Main Authors: Berg, David T, Gerlitz, Bruce, Sharma, Ganesh R, Richardson, Mark A, Stephens, Eddie J, Grubbs, Renee L, Holmes, Kimberly C, Fynboe, Kelly, Montani, Dominick, Cramer, Martin S, Engle, Steven D, Jakubowski, Joseph A, Heuer, Josef G, Grinnell, Brian W
Format: Journal Article
Language:English
Published: United States 01.03.2006
Subjects:
Acute Disease
Animals
Base Sequence
Biomarkers
Cecum
Disease Models, Animal
Female
Hepatocyte Nuclear Factor 3-beta - antagonists & inhibitors
Hepatocyte Nuclear Factor 3-beta - genetics
Hepatocyte Nuclear Factor 3-beta - physiology
Ligation
Molecular Sequence Data
Predictive Value of Tests
Prognosis
Protein C - antagonists & inhibitors
Protein C - biosynthesis
Protein C - genetics
Protein C - physiology
Punctures
Rats
Rats, Sprague-Dawley
RNA, Messenger - antagonists & inhibitors
RNA, Messenger - biosynthesis
RNA, Small Interfering - pharmacology
Sepsis - diagnosis
Sepsis - metabolism
Sepsis - mortality
ISSN:1556-6811
Online Access:Get more information
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Summary:Low levels of protein C (PC) predict outcome as early as 10 h after insult in a rat polymicrobial sepsis model and were associated with suppression of PC mRNA, upstream transcription factor FoxA2, and cofactor hepatocyte nuclear factor 6 (HNF6). Small interfering RNA suppression of FoxA2 in isolated hepatocytes demonstrated regulation of both its cofactor HNF6 and PC. Our data suggest that reduced FoxA2 may be important in the suppression of PC and resulting poor outcome in sepsis.
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ISSN:1556-6811
DOI:10.1128/CVI.13.3.426-432.2006