Inactivated tick-borne encephalitis vaccine elicits several overlapping waves of T cell response

The development and implementation of vaccines have been growing exponentially, remaining one of the major successes of healthcare over the last century. Nowadays, active regular immunizations prevent epidemics of many viral diseases, including tick-borne encephalitis (TBE). Along with the generatio...

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Vydané v:	Frontiers in immunology Ročník 13; s. 970285
Hlavní autori:	Sycheva, Anastasiia L., Komech, Ekaterina A., Pogorelyy, Mikhail V., Minervina, Anastasia A., Urazbakhtin, Shamil Z., Salnikova, Maria A., Vorovitch, Mikhail F., Kopantzev, Eugene P., Zvyagin, Ivan V., Komkov, Alexander Y., Mamedov, Ilgar Z., Lebedev, Yuri B.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Switzerland Frontiers Media S.A 24.08.2022
Predmet:	Antibodies, Viral CD8-Positive T-Lymphocytes clonal expansion Encephalitis Viruses, Tick-Borne Encephalitis, Tick-Borne - prevention & control Humans immunological memory Immunology T cell immune response TBE vaccination TCR motif TCR repertoire Viral Vaccines TBE vaccination tick-borne encephalitis TCR motif T cell immune response immunological memory clonal expansion TCR repertoire
ISSN:	1664-3224, 1664-3224
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Popis
Shrnutí:	The development and implementation of vaccines have been growing exponentially, remaining one of the major successes of healthcare over the last century. Nowadays, active regular immunizations prevent epidemics of many viral diseases, including tick-borne encephalitis (TBE). Along with the generation of virus-specific antibodies, a highly effective vaccine should induce T cell responses providing long-term immune defense. In this study, we performed longitudinal high-throughput T cell receptor (TCR) sequencing to characterize changes in individual T cell repertoires of 11 donors immunized with an inactivated TBE vaccine. After two-step immunization, we found significant clonal expansion of both CD4 + and CD8 + T cells, ranging from 302 to 1706 vaccine-associated TCRβ clonotypes in different donors. We detected several waves of T cell clonal expansion generated by distinct groups of vaccine-responding clones. Both CD4 + and CD8 + vaccine-responding T cell clones formed 17 motifs in TCRβ sequences shared by donors with identical HLA alleles. Our results indicate that TBE vaccination leads to a robust T cell response due to the production of a variety of T cell clones with a memory phenotype, which recognize a large set of epitopes.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Veronika Zarnitsyna, Emory University, United States Reviewed by: Rama S Akondy, Ashoka University, India; Tatjana Avsic Zupanc, University of Ljubljana, Slovenia This article was submitted to T Cell Biology, a section of the journal Frontiers in Immunology
ISSN:	1664-3224 1664-3224
DOI:	10.3389/fimmu.2022.970285