Detection of drug effects on gastric emptying and contractility using a wireless motility capsule

Background A wireless motility capsule is a new method for ambulatory assessment of transit times and motility throughout the gastrointestinal tract. The objective of this study was to evaluate the ability of a wireless motility capsule to detect drug effects on gastric emptying time (GET) and gastr...

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Vydáno v:	BMC gastroenterology Ročník 14; číslo 1; s. 2
Hlavní autoři:	Rozov-Ung, Inna, Mreyoud, Amjad, Moore, John, Wilding, Gregory E, Khawam, Elias, Lackner, Jeffrey M, Semler, John R, Sitrin, Michael D
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 02.01.2014 Springer Nature B.V
Témata:	Adult Aged Body Temperature Capsule Endoscopy - methods Data analysis Drug dosages Erythromycin - pharmacology Family medical history Female Gastric Emptying - drug effects Gastroenterology Gastroesophageal disorders Gastrointestinal surgery Gastrointestinal Transit - drug effects Hepatology Humans Hydrogen-Ion Concentration Internal Medicine Male Mass spectrometry Medicine Medicine & Public Health Middle Aged Monitoring, Ambulatory - instrumentation Morphine - pharmacology Motility Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - physiology Nuclear medicine Patients Pressure Research Article Sodium Chloride - pharmacology Stomach - drug effects Stomach - physiology Studies Time Factors Wireless Technology Young Adult Morphine Erythromycin Wireless motility capsule Gastric motility
ISSN:	1471-230X, 1471-230X
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Abstract	Background A wireless motility capsule is a new method for ambulatory assessment of transit times and motility throughout the gastrointestinal tract. The objective of this study was to evaluate the ability of a wireless motility capsule to detect drug effects on gastric emptying time (GET) and gastric contractility. Methods 15 healthy adults were administered in random order saline, erythromycin IV 150 mg, or morphine IV 0.05 mg/kg BW. Subjects ate a standard meal after each infusion, and subsequently ingested the motility capsule. Data were recorded for 8 hours, and the results were analyzed using the manufacturer’s software. Results GET was significantly faster after erythromycin than either saline or morphine. Morphine tended to delay emptying of the capsule compared to saline. There was a trend toward a greater frequency of gastric contractions with erythromycin and a reduced frequency of gastric contractions with morphine that did not reach statistical significance. Conclusions A wireless motility capsule successfully detected acceleration of gastric emptying induced by erythromycin, and retardation of gastric motility caused by morphine. These results indicate that a wireless motility capsule is a promising technique to assess pharmacologic effects on gastric transit and contractility and aid in development of drugs for gastric motor disorders.
AbstractList	A wireless motility capsule is a new method for ambulatory assessment of transit times and motility throughout the gastrointestinal tract. The objective of this study was to evaluate the ability of a wireless motility capsule to detect drug effects on gastric emptying time (GET) and gastric contractility.BACKGROUNDA wireless motility capsule is a new method for ambulatory assessment of transit times and motility throughout the gastrointestinal tract. The objective of this study was to evaluate the ability of a wireless motility capsule to detect drug effects on gastric emptying time (GET) and gastric contractility.15 healthy adults were administered in random order saline, erythromycin IV 150 mg, or morphine IV 0.05 mg/kg BW. Subjects ate a standard meal after each infusion, and subsequently ingested the motility capsule. Data were recorded for 8 hours, and the results were analyzed using the manufacturer's software.METHODS15 healthy adults were administered in random order saline, erythromycin IV 150 mg, or morphine IV 0.05 mg/kg BW. Subjects ate a standard meal after each infusion, and subsequently ingested the motility capsule. Data were recorded for 8 hours, and the results were analyzed using the manufacturer's software.GET was significantly faster after erythromycin than either saline or morphine. Morphine tended to delay emptying of the capsule compared to saline. There was a trend toward a greater frequency of gastric contractions with erythromycin and a reduced frequency of gastric contractions with morphine that did not reach statistical significance.RESULTSGET was significantly faster after erythromycin than either saline or morphine. Morphine tended to delay emptying of the capsule compared to saline. There was a trend toward a greater frequency of gastric contractions with erythromycin and a reduced frequency of gastric contractions with morphine that did not reach statistical significance.A wireless motility capsule successfully detected acceleration of gastric emptying induced by erythromycin, and retardation of gastric motility caused by morphine. These results indicate that a wireless motility capsule is a promising technique to assess pharmacologic effects on gastric transit and contractility and aid in development of drugs for gastric motor disorders.CONCLUSIONSA wireless motility capsule successfully detected acceleration of gastric emptying induced by erythromycin, and retardation of gastric motility caused by morphine. These results indicate that a wireless motility capsule is a promising technique to assess pharmacologic effects on gastric transit and contractility and aid in development of drugs for gastric motor disorders. Background A wireless motility capsule is a new method for ambulatory assessment of transit times and motility throughout the gastrointestinal tract. The objective of this study was to evaluate the ability of a wireless motility capsule to detect drug effects on gastric emptying time (GET) and gastric contractility. Methods 15 healthy adults were administered in random order saline, erythromycin IV 150 mg, or morphine IV 0.05 mg/kg BW. Subjects ate a standard meal after each infusion, and subsequently ingested the motility capsule. Data were recorded for 8 hours, and the results were analyzed using the manufacturer’s software. Results GET was significantly faster after erythromycin than either saline or morphine. Morphine tended to delay emptying of the capsule compared to saline. There was a trend toward a greater frequency of gastric contractions with erythromycin and a reduced frequency of gastric contractions with morphine that did not reach statistical significance. Conclusions A wireless motility capsule successfully detected acceleration of gastric emptying induced by erythromycin, and retardation of gastric motility caused by morphine. These results indicate that a wireless motility capsule is a promising technique to assess pharmacologic effects on gastric transit and contractility and aid in development of drugs for gastric motor disorders. A wireless motility capsule is a new method for ambulatory assessment of transit times and motility throughout the gastrointestinal tract. The objective of this study was to evaluate the ability of a wireless motility capsule to detect drug effects on gastric emptying time (GET) and gastric contractility. 15 healthy adults were administered in random order saline, erythromycin IV 150 mg, or morphine IV 0.05 mg/kg BW. Subjects ate a standard meal after each infusion, and subsequently ingested the motility capsule. Data were recorded for 8 hours, and the results were analyzed using the manufacturer's software. GET was significantly faster after erythromycin than either saline or morphine. Morphine tended to delay emptying of the capsule compared to saline. There was a trend toward a greater frequency of gastric contractions with erythromycin and a reduced frequency of gastric contractions with morphine that did not reach statistical significance. A wireless motility capsule successfully detected acceleration of gastric emptying induced by erythromycin, and retardation of gastric motility caused by morphine. These results indicate that a wireless motility capsule is a promising technique to assess pharmacologic effects on gastric transit and contractility and aid in development of drugs for gastric motor disorders. Doc number: 2 Abstract Background: A wireless motility capsule is a new method for ambulatory assessment of transit times and motility throughout the gastrointestinal tract. The objective of this study was to evaluate the ability of a wireless motility capsule to detect drug effects on gastric emptying time (GET) and gastric contractility. Methods: 15 healthy adults were administered in random order saline, erythromycin IV 150 mg, or morphine IV 0.05 mg/kg BW. Subjects ate a standard meal after each infusion, and subsequently ingested the motility capsule. Data were recorded for 8 hours, and the results were analyzed using the manufacturer's software. Results: GET was significantly faster after erythromycin than either saline or morphine. Morphine tended to delay emptying of the capsule compared to saline. There was a trend toward a greater frequency of gastric contractions with erythromycin and a reduced frequency of gastric contractions with morphine that did not reach statistical significance. Conclusions: A wireless motility capsule successfully detected acceleration of gastric emptying induced by erythromycin, and retardation of gastric motility caused by morphine. These results indicate that a wireless motility capsule is a promising technique to assess pharmacologic effects on gastric transit and contractility and aid in development of drugs for gastric motor disorders.
ArticleNumber	2
Author	Sitrin, Michael D Khawam, Elias Rozov-Ung, Inna Semler, John R Lackner, Jeffrey M Wilding, Gregory E Moore, John Mreyoud, Amjad
AuthorAffiliation	1 Division of Gastroenterology, Hepatology, and Nutrition, University at Buffalo, State University of New York, 462 Grider, Rm 132-7, Buffalo, NY 14215, USA 2 Department of Biostatistics, University at Buffalo, Buffalo, USA 3 SmartPill Corporation, Buffalo, NY, USA
AuthorAffiliation_xml	– name: 1 Division of Gastroenterology, Hepatology, and Nutrition, University at Buffalo, State University of New York, 462 Grider, Rm 132-7, Buffalo, NY 14215, USA – name: 2 Department of Biostatistics, University at Buffalo, Buffalo, USA – name: 3 SmartPill Corporation, Buffalo, NY, USA
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Copyright	Rozov-Ung et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 2014 Rozov-Ung et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2014 Rozov-Ung et al.; licensee BioMed Central Ltd. 2014 Rozov-Ung et al.; licensee BioMed Central Ltd.
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Keywords	Morphine Erythromycin Wireless motility capsule Gastric motility
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Snippet	Background A wireless motility capsule is a new method for ambulatory assessment of transit times and motility throughout the gastrointestinal tract. The... A wireless motility capsule is a new method for ambulatory assessment of transit times and motility throughout the gastrointestinal tract. The objective of... Doc number: 2 Abstract Background: A wireless motility capsule is a new method for ambulatory assessment of transit times and motility throughout the...
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SubjectTerms	Adult Aged Body Temperature Capsule Endoscopy - methods Data analysis Drug dosages Erythromycin - pharmacology Family medical history Female Gastric Emptying - drug effects Gastroenterology Gastroesophageal disorders Gastrointestinal surgery Gastrointestinal Transit - drug effects Hepatology Humans Hydrogen-Ion Concentration Internal Medicine Male Mass spectrometry Medicine Medicine & Public Health Middle Aged Monitoring, Ambulatory - instrumentation Morphine - pharmacology Motility Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - physiology Nuclear medicine Patients Pressure Research Article Sodium Chloride - pharmacology Stomach - drug effects Stomach - physiology Studies Time Factors Wireless Technology Young Adult
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Title	Detection of drug effects on gastric emptying and contractility using a wireless motility capsule
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