Detection of drug effects on gastric emptying and contractility using a wireless motility capsule

Background A wireless motility capsule is a new method for ambulatory assessment of transit times and motility throughout the gastrointestinal tract. The objective of this study was to evaluate the ability of a wireless motility capsule to detect drug effects on gastric emptying time (GET) and gastr...

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Published in:BMC gastroenterology Vol. 14; no. 1; p. 2
Main Authors: Rozov-Ung, Inna, Mreyoud, Amjad, Moore, John, Wilding, Gregory E, Khawam, Elias, Lackner, Jeffrey M, Semler, John R, Sitrin, Michael D
Format: Journal Article
Language:English
Published: London BioMed Central 02.01.2014
Springer Nature B.V
Subjects:
Adult
Aged
Body Temperature
Capsule Endoscopy - methods
Data analysis
Drug dosages
Erythromycin - pharmacology
Family medical history
Female
Gastric Emptying - drug effects
Gastroenterology
Gastroesophageal disorders
Gastrointestinal surgery
Gastrointestinal Transit - drug effects
Hepatology
Humans
Hydrogen-Ion Concentration
Internal Medicine
Male
Mass spectrometry
Medicine
Medicine & Public Health
Middle Aged
Monitoring, Ambulatory - instrumentation
Morphine - pharmacology
Motility
Muscle Contraction - drug effects
Muscle, Smooth - drug effects
Muscle, Smooth - physiology
Nuclear medicine
Patients
Pressure
Research Article
Sodium Chloride - pharmacology
Stomach - drug effects
Stomach - physiology
Studies
Time Factors
Wireless Technology
Young Adult
Morphine
Erythromycin
Wireless motility capsule
Gastric motility
ISSN:1471-230X, 1471-230X
Online Access:Get full text
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Summary:Background A wireless motility capsule is a new method for ambulatory assessment of transit times and motility throughout the gastrointestinal tract. The objective of this study was to evaluate the ability of a wireless motility capsule to detect drug effects on gastric emptying time (GET) and gastric contractility. Methods 15 healthy adults were administered in random order saline, erythromycin IV 150 mg, or morphine IV 0.05 mg/kg BW. Subjects ate a standard meal after each infusion, and subsequently ingested the motility capsule. Data were recorded for 8 hours, and the results were analyzed using the manufacturer’s software. Results GET was significantly faster after erythromycin than either saline or morphine. Morphine tended to delay emptying of the capsule compared to saline. There was a trend toward a greater frequency of gastric contractions with erythromycin and a reduced frequency of gastric contractions with morphine that did not reach statistical significance. Conclusions A wireless motility capsule successfully detected acceleration of gastric emptying induced by erythromycin, and retardation of gastric motility caused by morphine. These results indicate that a wireless motility capsule is a promising technique to assess pharmacologic effects on gastric transit and contractility and aid in development of drugs for gastric motor disorders.
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ISSN:1471-230X
1471-230X
DOI:10.1186/1471-230X-14-2