Development of Host Immune Response to Bacteriophage in a Lung Transplant Recipient on Adjunctive Phage Therapy for a Multidrug-Resistant Pneumonia

Bacteriophage therapy is the use of viruses to kill bacteria for the treatment of antibiotic-resistant infections. Little is known about the human immune response following phage therapy. We report the development of phage-specific CD4 T cells alongside rising phage-specific immunoglobulin G and neu...

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Veröffentlicht in:The Journal of infectious diseases Jg. 227; H. 3; S. 311
Hauptverfasser: Dan, Jennifer M, Lehman, Susan M, Al-Kolla, Rita, Penziner, Samuel, Afshar, Kamyar, Yung, Gordon, Golts, Eugene, Law, Nancy, Logan, Cathy, Kovach, Zsuzsanna, Mearns, Gill, Schooley, Robert T, Aslam, Saima, Crotty, Shane
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.02.2023
Schlagworte:
Bacteriophages - physiology
Humans
Immunity
Lung - microbiology
Phage Therapy
Pneumonia
Pseudomonas aeruginosa - physiology
Pseudomonas Infections - microbiology
Pseudomonas Infections - therapy
Transplant Recipients
AIM
immune response
phage therapy
anti-phage antibody
PBMC
bacteriophage
T follicular helper cell
ISSN:1537-6613, 1537-6613
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Abstract Bacteriophage therapy is the use of viruses to kill bacteria for the treatment of antibiotic-resistant infections. Little is known about the human immune response following phage therapy. We report the development of phage-specific CD4 T cells alongside rising phage-specific immunoglobulin G and neutralizing antibodies in response to adjunctive bacteriophage therapy used to treat a multidrug-resistant Pseudomonas aeruginosa pneumonia in a lung transplant recipient. Clinically, treatment was considered a success despite the development phage-specific immune responses.
AbstractList Bacteriophage therapy is the use of viruses to kill bacteria for the treatment of antibiotic-resistant infections. Little is known about the human immune response following phage therapy. We report the development of phage-specific CD4 T cells alongside rising phage-specific immunoglobulin G and neutralizing antibodies in response to adjunctive bacteriophage therapy used to treat a multidrug-resistant Pseudomonas aeruginosa pneumonia in a lung transplant recipient. Clinically, treatment was considered a success despite the development phage-specific immune responses.
Bacteriophage therapy is the use of viruses to kill bacteria for the treatment of antibiotic-resistant infections. Little is known about the human immune response following phage therapy. We report the development of phage-specific CD4 T cells alongside rising phage-specific immunoglobulin G and neutralizing antibodies in response to adjunctive bacteriophage therapy used to treat a multidrug-resistant Pseudomonas aeruginosa pneumonia in a lung transplant recipient. Clinically, treatment was considered a success despite the development phage-specific immune responses.Bacteriophage therapy is the use of viruses to kill bacteria for the treatment of antibiotic-resistant infections. Little is known about the human immune response following phage therapy. We report the development of phage-specific CD4 T cells alongside rising phage-specific immunoglobulin G and neutralizing antibodies in response to adjunctive bacteriophage therapy used to treat a multidrug-resistant Pseudomonas aeruginosa pneumonia in a lung transplant recipient. Clinically, treatment was considered a success despite the development phage-specific immune responses.
Author Crotty, Shane
Lehman, Susan M
Penziner, Samuel
Golts, Eugene
Kovach, Zsuzsanna
Logan, Cathy
Al-Kolla, Rita
Schooley, Robert T
Yung, Gordon
Law, Nancy
Dan, Jennifer M
Aslam, Saima
Afshar, Kamyar
Mearns, Gill
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  fullname: Logan, Cathy
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Copyright The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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immune response
phage therapy
anti-phage antibody
PBMC
bacteriophage
T follicular helper cell
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References 36083993 - J Infect Dis. 2023 Feb 1;227(3):309-310. doi: 10.1093/infdis/jiac369
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SubjectTerms Bacteriophages - physiology
Humans
Immunity
Lung - microbiology
Phage Therapy
Pneumonia
Pseudomonas aeruginosa - physiology
Pseudomonas Infections - microbiology
Pseudomonas Infections - therapy
Transplant Recipients
Title Development of Host Immune Response to Bacteriophage in a Lung Transplant Recipient on Adjunctive Phage Therapy for a Multidrug-Resistant Pneumonia
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