Development of Host Immune Response to Bacteriophage in a Lung Transplant Recipient on Adjunctive Phage Therapy for a Multidrug-Resistant Pneumonia

Bacteriophage therapy is the use of viruses to kill bacteria for the treatment of antibiotic-resistant infections. Little is known about the human immune response following phage therapy. We report the development of phage-specific CD4 T cells alongside rising phage-specific immunoglobulin G and neu...

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Bibliographic Details
Published in:The Journal of infectious diseases Vol. 227; no. 3; p. 311
Main Authors: Dan, Jennifer M, Lehman, Susan M, Al-Kolla, Rita, Penziner, Samuel, Afshar, Kamyar, Yung, Gordon, Golts, Eugene, Law, Nancy, Logan, Cathy, Kovach, Zsuzsanna, Mearns, Gill, Schooley, Robert T, Aslam, Saima, Crotty, Shane
Format: Journal Article
Language:English
Published: United States 01.02.2023
Subjects:
Bacteriophages - physiology
Humans
Immunity
Lung - microbiology
Phage Therapy
Pneumonia
Pseudomonas aeruginosa - physiology
Pseudomonas Infections - microbiology
Pseudomonas Infections - therapy
Transplant Recipients
AIM
immune response
phage therapy
anti-phage antibody
PBMC
bacteriophage
T follicular helper cell
ISSN:1537-6613, 1537-6613
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Summary:Bacteriophage therapy is the use of viruses to kill bacteria for the treatment of antibiotic-resistant infections. Little is known about the human immune response following phage therapy. We report the development of phage-specific CD4 T cells alongside rising phage-specific immunoglobulin G and neutralizing antibodies in response to adjunctive bacteriophage therapy used to treat a multidrug-resistant Pseudomonas aeruginosa pneumonia in a lung transplant recipient. Clinically, treatment was considered a success despite the development phage-specific immune responses.
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ISSN:1537-6613
1537-6613
DOI:10.1093/infdis/jiac368