Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

Coronavirus disease 2019 (COVID-19) is currently a global pandemic, but human immune responses to the virus remain poorly understood. We used high-dimensional cytometry to analyze 125 COVID-19 patients and compare them with recovered and healthy individuals. Integrated analysis of ~200 immune and ~5...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) Vol. 369; no. 6508
Main Authors: Mathew, Divij, Giles, Josephine R, Baxter, Amy E, Oldridge, Derek A, Greenplate, Allison R, Wu, Jennifer E, Alanio, Cécile, Kuri-Cervantes, Leticia, Pampena, M Betina, D'Andrea, Kurt, Manne, Sasikanth, Chen, Zeyu, Huang, Yinghui Jane, Reilly, John P, Weisman, Ariel R, Ittner, Caroline A G, Kuthuru, Oliva, Dougherty, Jeanette, Nzingha, Kito, Han, Nicholas, Kim, Justin, Pattekar, Ajinkya, Goodwin, Eileen C, Anderson, Elizabeth M, Weirick, Madison E, Gouma, Sigrid, Arevalo, Claudia P, Bolton, Marcus J, Chen, Fang, Lacey, Simon F, Ramage, Holly, Cherry, Sara, Hensley, Scott E, Apostolidis, Sokratis A, Huang, Alexander C, Vella, Laura A, Betts, Michael R, Meyer, Nuala J, Wherry, E John
Format: Journal Article
Language:English
Published: United States 04.09.2020
Subjects:
Adaptive Immunity
Adult
Aged
Aged, 80 and over
Antibodies, Viral - blood
B-Lymphocyte Subsets - immunology
B-Lymphocytes - immunology
Betacoronavirus - immunology
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Coronavirus Infections - immunology
COVID-19
Cytokines - blood
Female
Humans
Immunologic Memory
Lymphocyte Activation
Male
Middle Aged
Pandemics
Plasma Cells - immunology
Pneumonia, Viral - immunology
SARS-CoV-2
Severity of Illness Index
T-Lymphocyte Subsets - immunology
T-Lymphocytes - immunology
T-Lymphocytes, Helper-Inducer - immunology
Time Factors
Young Adult
ISSN:1095-9203, 1095-9203
Online Access:Get more information
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Summary:Coronavirus disease 2019 (COVID-19) is currently a global pandemic, but human immune responses to the virus remain poorly understood. We used high-dimensional cytometry to analyze 125 COVID-19 patients and compare them with recovered and healthy individuals. Integrated analysis of ~200 immune and ~50 clinical features revealed activation of T cell and B cell subsets in a proportion of patients. A subgroup of patients had T cell activation characteristic of acute viral infection and plasmablast responses reaching >30% of circulating B cells. However, another subgroup had lymphocyte activation comparable with that in uninfected individuals. Stable versus dynamic immunological signatures were identified and linked to trajectories of disease severity change. Our analyses identified three immunotypes associated with poor clinical trajectories versus improving health. These immunotypes may have implications for the design of therapeutics and vaccines for COVID-19.
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ISSN:1095-9203
1095-9203
DOI:10.1126/science.abc8511