Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

Coronavirus disease 2019 (COVID-19) is currently a global pandemic, but human immune responses to the virus remain poorly understood. We used high-dimensional cytometry to analyze 125 COVID-19 patients and compare them with recovered and healthy individuals. Integrated analysis of ~200 immune and ~5...

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Vydáno v:	Science (American Association for the Advancement of Science) Ročník 369; číslo 6508
Hlavní autoři:	Mathew, Divij, Giles, Josephine R, Baxter, Amy E, Oldridge, Derek A, Greenplate, Allison R, Wu, Jennifer E, Alanio, Cécile, Kuri-Cervantes, Leticia, Pampena, M Betina, D'Andrea, Kurt, Manne, Sasikanth, Chen, Zeyu, Huang, Yinghui Jane, Reilly, John P, Weisman, Ariel R, Ittner, Caroline A G, Kuthuru, Oliva, Dougherty, Jeanette, Nzingha, Kito, Han, Nicholas, Kim, Justin, Pattekar, Ajinkya, Goodwin, Eileen C, Anderson, Elizabeth M, Weirick, Madison E, Gouma, Sigrid, Arevalo, Claudia P, Bolton, Marcus J, Chen, Fang, Lacey, Simon F, Ramage, Holly, Cherry, Sara, Hensley, Scott E, Apostolidis, Sokratis A, Huang, Alexander C, Vella, Laura A, Betts, Michael R, Meyer, Nuala J, Wherry, E John
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 04.09.2020
Témata:	Adaptive Immunity Adult Aged Aged, 80 and over Antibodies, Viral - blood B-Lymphocyte Subsets - immunology B-Lymphocytes - immunology Betacoronavirus - immunology CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Coronavirus Infections - immunology COVID-19 Cytokines - blood Female Humans Immunologic Memory Lymphocyte Activation Male Middle Aged Pandemics Plasma Cells - immunology Pneumonia, Viral - immunology SARS-CoV-2 Severity of Illness Index T-Lymphocyte Subsets - immunology T-Lymphocytes - immunology T-Lymphocytes, Helper-Inducer - immunology Time Factors Young Adult
ISSN:	1095-9203, 1095-9203
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Popis
Shrnutí:	Coronavirus disease 2019 (COVID-19) is currently a global pandemic, but human immune responses to the virus remain poorly understood. We used high-dimensional cytometry to analyze 125 COVID-19 patients and compare them with recovered and healthy individuals. Integrated analysis of ~200 immune and ~50 clinical features revealed activation of T cell and B cell subsets in a proportion of patients. A subgroup of patients had T cell activation characteristic of acute viral infection and plasmablast responses reaching >30% of circulating B cells. However, another subgroup had lymphocyte activation comparable with that in uninfected individuals. Stable versus dynamic immunological signatures were identified and linked to trajectories of disease severity change. Our analyses identified three immunotypes associated with poor clinical trajectories versus improving health. These immunotypes may have implications for the design of therapeutics and vaccines for COVID-19.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	1095-9203 1095-9203
DOI:	10.1126/science.abc8511