oncoPredict: an R package for predicting in vivo or cancer patient drug response and biomarkers from cell line screening data

Cell line drug screening datasets can be utilized for a range of different drug discovery applications from drug biomarker discovery to building translational models of drug response. Previously, we described three separate methodologies to (1) correct for general levels of drug sensitivity to enabl...

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Bibliographic Details
Published in:	Briefings in bioinformatics Vol. 22; no. 6
Main Authors:	Maeser, Danielle, Gruener, Robert F, Huang, Rong Stephanie
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 05.11.2021
Subjects:	Antineoplastic Agents - therapeutic use Biomarkers, Tumor - metabolism Cell Line, Tumor Humans Problem Solving Protocol Software biomarker identification drug discovery drug response prediction
ISSN:	1467-5463, 1477-4054, 1477-4054
Online Access:	Get full text
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Abstract	Cell line drug screening datasets can be utilized for a range of different drug discovery applications from drug biomarker discovery to building translational models of drug response. Previously, we described three separate methodologies to (1) correct for general levels of drug sensitivity to enable drug-specific biomarker discovery, (2) predict clinical drug response in patients and (3) associate these predictions with clinical features to perform in vivo drug biomarker discovery. Here, we unite and update these methodologies into one R package (oncoPredict) to facilitate the development and adoption of these tools. This new OncoPredict R package can be applied to various in vitro and in vivo contexts for drug and biomarker discovery.
AbstractList	Cell line drug screening datasets can be utilized for a range of different drug discovery applications from drug biomarker discovery to building translational models of drug response. Previously, we described three separate methodologies to (1) correct for general levels of drug sensitivity to enable drug-specific biomarker discovery, (2) predict clinical drug response in patients and (3) associate these predictions with clinical features to perform in vivo drug biomarker discovery. Here, we unite and update these methodologies into one R package (oncoPredict) to facilitate the development and adoption of these tools. This new OncoPredict R package can be applied to various in vitro and in vivo contexts for drug and biomarker discovery. Cell line drug screening datasets can be utilized for a range of different drug discovery applications from drug biomarker discovery to building translational models of drug response. Previously, we described three separate methodologies to (1) correct for general levels of drug sensitivity to enable drug-specific biomarker discovery, (2) predict clinical drug response in patients and (3) associate these predictions with clinical features to perform in vivo drug biomarker discovery. Here, we unite and update these methodologies into one R package (oncoPredict) to facilitate the development and adoption of these tools. This new OncoPredict R package can be applied to various in vitro and in vivo contexts for drug and biomarker discovery.Cell line drug screening datasets can be utilized for a range of different drug discovery applications from drug biomarker discovery to building translational models of drug response. Previously, we described three separate methodologies to (1) correct for general levels of drug sensitivity to enable drug-specific biomarker discovery, (2) predict clinical drug response in patients and (3) associate these predictions with clinical features to perform in vivo drug biomarker discovery. Here, we unite and update these methodologies into one R package (oncoPredict) to facilitate the development and adoption of these tools. This new OncoPredict R package can be applied to various in vitro and in vivo contexts for drug and biomarker discovery.
Author	Maeser, Danielle Gruener, Robert F Huang, Rong Stephanie
Author_xml	– sequence: 1 givenname: Danielle surname: Maeser fullname: Maeser, Danielle organization: Department of Bioinformatics & Computational Biology, University of Minnesota, Minneapolis, MN 55455, USA – sequence: 2 givenname: Robert F surname: Gruener fullname: Gruener, Robert F organization: Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA – sequence: 3 givenname: Rong Stephanie orcidid: 0000-0002-9862-0368 surname: Huang fullname: Huang, Rong Stephanie organization: Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/34260682$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1158/2159-8290.CD-15-0235 10.1371/journal.pcbi.1007803 10.1007/s12551-018-0446-z 10.3390/cancers13040885 10.1038/nbt.2877 10.1186/gb-2014-15-3-r47 10.1093/nar/gkv1507 10.1016/j.pharmthera.2018.06.014 10.1371/journal.pone.0050701 10.1186/1471-2407-13-549 10.1093/bib/bbw065 10.1038/s41698-020-0122-1 10.1101/gr.221077.117 10.1186/s13059-016-1050-9 10.1093/bib/bbz153 10.1038/ng.2764 10.1016/j.cell.2016.06.017 10.1371/journal.pone.0107468
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References	Geeleher (2021110815063688000_ref11) 2014; 15 2021110815063688000_ref16 Koti (2021110815063688000_ref21) 2013; 13 Ling (2021110815063688000_ref1) 2018; 191 Office of Cancer Genomics (2021110815063688000_ref15) Lin (2021110815063688000_ref18) 2012; 7 NCI DREAM Community (2021110815063688000_ref4) 2014; 32 Schätzle (2021110815063688000_ref20) 2020; 16 Jang (2021110815063688000_ref5) 2014 Geeleher (2021110815063688000_ref13) 2014; 9 2021110815063688000_ref17 Gruener (2021110815063688000_ref14) 2021; 13 Seashore-Ludlow (2021110815063688000_ref2) 2015; 5 The Cancer Genome Atlas Research Network (2021110815063688000_ref22) 2013; 45 Azuaje (2021110815063688000_ref6) 2017; 18 Geeleher (2021110815063688000_ref10) 2016; 17 Ali (2021110815063688000_ref7) 2019; 11 Adam (2021110815063688000_ref8) 2020; 4 Colaprico (2021110815063688000_ref23) 2016; 44 Güvenç Paltun (2021110815063688000_ref9) 2021; 22 Geeleher (2021110815063688000_ref12) 2017; 27 Cule (2021110815063688000_ref19) 2021 Iorio (2021110815063688000_ref3) 2016; 166
References_xml	– volume: 5 start-page: 1210 issue: 11 year: 2015 ident: 2021110815063688000_ref2 publication-title: Cancer Discov doi: 10.1158/2159-8290.CD-15-0235 – volume-title: ridge: Ridge Regression with Automatic Selection of the Penalty Parameter. R package version 2.9 year: 2021 ident: 2021110815063688000_ref19 – volume: 16 start-page: e1007803 issue: 4 year: 2020 ident: 2021110815063688000_ref20 article-title: Methodological challenges in translational drug response modeling in cancer: a systematic analysis with FORESEE publication-title: PLoS Comput Biol doi: 10.1371/journal.pcbi.1007803 – volume: 11 start-page: 31 issue: 1 year: 2019 ident: 2021110815063688000_ref7 publication-title: Biophys Rev doi: 10.1007/s12551-018-0446-z – volume: 13 start-page: 4 issue: 4 year: 2021 ident: 2021110815063688000_ref14 article-title: Facilitating drug discovery in breast cancer by virtually screening patients using in vitro drug response modeling publication-title: Cancer doi: 10.3390/cancers13040885 – volume: 32 start-page: 1202 issue: 12 year: 2014 ident: 2021110815063688000_ref4 publication-title: Nat Biotechnol doi: 10.1038/nbt.2877 – volume: 15 start-page: R47 year: 2014 ident: 2021110815063688000_ref11 article-title: Clinical drug response can be predicted using baseline gene expression levels and in vitro drug sensitivity in cell lines publication-title: Genome Biol doi: 10.1186/gb-2014-15-3-r47 – volume-title: Drug Download Page—Cancerrxgene—Genomics of Drug Sensitivity in Cancer ident: 2021110815063688000_ref17 – volume: 44 start-page: e71 issue: 8 year: 2016 ident: 2021110815063688000_ref23 article-title: TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data publication-title: Nucleic Acids Res doi: 10.1093/nar/gkv1507 – volume: 191 start-page: 178 year: 2018 ident: 2021110815063688000_ref1 article-title: More than fishing for a cure: the promises and pitfalls of high throughput cancer cell line screens publication-title: Pharmacol Ther doi: 10.1016/j.pharmthera.2018.06.014 – volume: 7 start-page: e50701 issue: 11 year: 2012 ident: 2021110815063688000_ref18 article-title: KRAS mutation is a predictor of oxaliplatin sensitivity in colon cancer cells publication-title: PLoS ONE doi: 10.1371/journal.pone.0050701 – ident: 2021110815063688000_ref16 – volume: 13 start-page: 549 year: 2013 ident: 2021110815063688000_ref21 article-title: Identification of the IGF1/PI3K/NF κB/ERK gene signalling networks associated with chemotherapy resistance and treatment response in high-grade serous epithelial ovarian cancer publication-title: BMC Cancer doi: 10.1186/1471-2407-13-549 – volume: 18 start-page: 820 issue: 5 year: 2017 ident: 2021110815063688000_ref6 publication-title: Brief Bioinform doi: 10.1093/bib/bbw065 – start-page: 63 year: 2014 ident: 2021110815063688000_ref5 article-title: Systematic assessment of analytical methods for drug sensitivity prediction from cancer cell line data publication-title: Pac Symp Biocomput – volume: 4 start-page: 1 issue: 1 year: 2020 ident: 2021110815063688000_ref8 article-title: Machine learning approaches to drug response prediction: challenges and recent progress publication-title: NPJ Precis Oncol doi: 10.1038/s41698-020-0122-1 – volume: 27 start-page: 1743 issue: 10 year: 2017 ident: 2021110815063688000_ref12 article-title: Discovering novel pharmacogenomic biomarkers by imputing drug response in cancer patients from large genomics studies publication-title: Genome Res doi: 10.1101/gr.221077.117 – volume: 17 start-page: 190 issue: 1 year: 2016 ident: 2021110815063688000_ref10 article-title: Cancer biomarker discovery is improved by accounting for variability in general levels of drug sensitivity in pre-clinical models publication-title: Genome Biol doi: 10.1186/s13059-016-1050-9 – ident: 2021110815063688000_ref15 – volume: 22 start-page: 346 issue: 1 year: 2021 ident: 2021110815063688000_ref9 article-title: Improving drug response prediction by integrating multiple data sources: matrix factorization, kernel and network-based approaches publication-title: Brief Bioinform doi: 10.1093/bib/bbz153 – volume: 45 start-page: 1113 issue: 10 year: 2013 ident: 2021110815063688000_ref22 article-title: The Cancer Genome Atlas Pan-Cancer analysis project publication-title: Nat Genet doi: 10.1038/ng.2764 – volume: 166 start-page: 740 issue: 3 year: 2016 ident: 2021110815063688000_ref3 publication-title: Cell doi: 10.1016/j.cell.2016.06.017 – volume: 9 start-page: e107468 issue: 9 year: 2014 ident: 2021110815063688000_ref13 article-title: pRRophetic: an R package for prediction of clinical chemotherapeutic response from tumor gene expression levels publication-title: PLoS ONE doi: 10.1371/journal.pone.0107468
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Snippet	Cell line drug screening datasets can be utilized for a range of different drug discovery applications from drug biomarker discovery to building translational...
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SubjectTerms	Antineoplastic Agents - therapeutic use Biomarkers, Tumor - metabolism Cell Line, Tumor Humans Problem Solving Protocol Software
Title	oncoPredict: an R package for predicting in vivo or cancer patient drug response and biomarkers from cell line screening data
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