Non-coding RNA in cancer

Majority of the human genome is transcribed to RNAs that do not encode proteins. These non-coding RNAs (ncRNAs) play crucial roles in regulating the initiation and progression of various cancers. Given the importance of the ncRNAs, the roles of ncRNAs in cancers have been reviewed elsewhere. Thus, i...

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Bibliographic Details
Published in:Essays in biochemistry Vol. 65; no. 4; p. 625
Main Authors: Yan, Huiwen, Bu, Pengcheng
Format: Journal Article
Language:English
Published: England 01.10.2021
Subjects:
microRNA
cancer
long non-coding RNA
piwi RNA
non-coding RNA
circular RNA
ISSN:1744-1358, 1744-1358
Online Access:Get more information
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Summary:Majority of the human genome is transcribed to RNAs that do not encode proteins. These non-coding RNAs (ncRNAs) play crucial roles in regulating the initiation and progression of various cancers. Given the importance of the ncRNAs, the roles of ncRNAs in cancers have been reviewed elsewhere. Thus, in this review, we mainly focus on the recent studies of the function, regulatory mechanism and therapeutic potential of the ncRNAs including microRNA (miRNA), long ncRNA (lncRNA), circular RNA (circRNA) and PIWI interacting RNA (piRNA), in different type of cancers.
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ISSN:1744-1358
1744-1358
DOI:10.1042/EBC20200032