Methodological Challenges in Protein Microarray and Immunohistochemistry for the Discovery of Novel Autoantibodies in Paediatric Acute Disseminated Encephalomyelitis

Acute disseminated encephalomyelitis (ADEM) is a rare autoimmune-mediated demyelinating disease affecting mainly children and young adults. Differentiation to multiple sclerosis is not always possible, due to overlapping clinical symptoms and recurrent and multiphasic forms. Until now, immunoglobuli...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 18; no. 3; p. 679
Main Authors:	Peschl, Patrick, Ramberger, Melanie, Höftberger, Romana, Jöhrer, Karin, Baumann, Matthias, Rostásy, Kevin, Reindl, Markus
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 22.03.2017 MDPI
Subjects:	Animals Antigens Autoantibodies - immunology Autoantigens - immunology Biomarkers Brain research Child Cluster Analysis Cross Reactions - immunology Disease Encephalomyelitis, Acute Disseminated - diagnosis Encephalomyelitis, Acute Disseminated - immunology Female Glycoproteins Humans Immunoglobulins Immunohistochemistry Male Medical research Membrane Proteins - immunology Multiple sclerosis Myelin-Oligodendrocyte Glycoprotein - immunology Nerve Tissue Proteins - immunology Neurology Patients Peptides Potassium Protein Array Analysis Proteins Proteins - immunology Proteome Proteomics - methods Rats Studies Austria acute disseminated encephalomyelitis autoantibody immunohistochemistry autoantigen protein microarray paediatric
ISSN:	1422-0067, 1661-6596, 1422-0067
Online Access:	Get full text
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