Epidemiological characteristics and molecular evolution mechanisms of carbapenem-resistant hypervirulent Klebsiella pneumoniae

Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP), a type of Klebsiella pneumoniae (KP) that exhibits hypervirulence and carbapenem resistance phenotypes, can cause severe infections, both hospital- and community-acquired infections. CR-hvKP has brought great challenges to global pu...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Frontiers in microbiology Ročník 13; s. 1003783
Hlavní autoři: Han, Yu-Ling, Wen, Xu-Hui, Zhao, Wen, Cao, Xi-Shan, Wen, Jian-Xun, Wang, Jun-Rui, Hu, Zhi-De, Zheng, Wen-Qi
Médium: Journal Article
Jazyk:angličtina
Vydáno: Frontiers Media S.A 12.09.2022
Témata:
carbapenem-resistant
evolution
hybrid plasmid
hypervirulent
Klebsiella pneumoniae
Microbiology
ISSN:1664-302X, 1664-302X
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP), a type of Klebsiella pneumoniae (KP) that exhibits hypervirulence and carbapenem resistance phenotypes, can cause severe infections, both hospital- and community-acquired infections. CR-hvKP has brought great challenges to global public health and is associated with significant morbidity and mortality. There are many mechanisms responsible for the evolution of the hypervirulence and carbapenem resistance phenotypes, such as the horizontal transfer of the plasmid carrying the carbapenem resistance gene to hypervirulent Klebsiella pneumoniae (hvKP) or carbapenemase-producing Klebsiella pneumoniae (CRKP) acquiring a hypervirulence plasmid carrying a virulence-encoding gene. Notably, KP can evolve into CR-hvKP by acquiring a hybrid plasmid carrying both the carbapenem resistance and hypervirulence genes. In this review, we summarize the evolutionary mechanisms of resistance and plasmid-borne virulence as well as the prevalence of CR-hvKP.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
Edited by: Ernesto Perez-Rueda, Universidad Nacional Autónoma de México, Mexico
This article was submitted to Evolutionary and Genomic Microbiology, a section of the journal Frontiers in Microbiology
Reviewed by: Carlos Henrique Camargo, Adolfo Lutz Institute, Brazil; Hamid Solgi, Isfahan University of Medical Sciences, Iran
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2022.1003783