Epidemiological characteristics and molecular evolution mechanisms of carbapenem-resistant hypervirulent Klebsiella pneumoniae

Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP), a type of Klebsiella pneumoniae (KP) that exhibits hypervirulence and carbapenem resistance phenotypes, can cause severe infections, both hospital- and community-acquired infections. CR-hvKP has brought great challenges to global pu...

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Published in:Frontiers in microbiology Vol. 13; p. 1003783
Main Authors: Han, Yu-Ling, Wen, Xu-Hui, Zhao, Wen, Cao, Xi-Shan, Wen, Jian-Xun, Wang, Jun-Rui, Hu, Zhi-De, Zheng, Wen-Qi
Format: Journal Article
Language:English
Published: Frontiers Media S.A 12.09.2022
Subjects:
carbapenem-resistant
evolution
hybrid plasmid
hypervirulent
Klebsiella pneumoniae
Microbiology
ISSN:1664-302X, 1664-302X
Online Access:Get full text
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Summary:Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP), a type of Klebsiella pneumoniae (KP) that exhibits hypervirulence and carbapenem resistance phenotypes, can cause severe infections, both hospital- and community-acquired infections. CR-hvKP has brought great challenges to global public health and is associated with significant morbidity and mortality. There are many mechanisms responsible for the evolution of the hypervirulence and carbapenem resistance phenotypes, such as the horizontal transfer of the plasmid carrying the carbapenem resistance gene to hypervirulent Klebsiella pneumoniae (hvKP) or carbapenemase-producing Klebsiella pneumoniae (CRKP) acquiring a hypervirulence plasmid carrying a virulence-encoding gene. Notably, KP can evolve into CR-hvKP by acquiring a hybrid plasmid carrying both the carbapenem resistance and hypervirulence genes. In this review, we summarize the evolutionary mechanisms of resistance and plasmid-borne virulence as well as the prevalence of CR-hvKP.
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Edited by: Ernesto Perez-Rueda, Universidad Nacional Autónoma de México, Mexico
This article was submitted to Evolutionary and Genomic Microbiology, a section of the journal Frontiers in Microbiology
Reviewed by: Carlos Henrique Camargo, Adolfo Lutz Institute, Brazil; Hamid Solgi, Isfahan University of Medical Sciences, Iran
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2022.1003783