Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications

The principle steroidal androgens are testosterone and its metabolite 5α-dihydrotestosterone (DHT), which is converted from testosterone by the enzyme 5α-reductase. Through the classic pathway with androgens crossing the plasma membrane and binding to the androgen receptor (AR) or via mechanisms ind...

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Vydané v:	Clinical science (1979) Ročník 131; číslo 13; s. 1405
Hlavní autori:	Lucas-Herald, Angela K, Alves-Lopes, Rheure, Montezano, Augusto C, Ahmed, S Faisal, Touyz, Rhian M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 01.07.2017
Predmet:	Androgens - physiology Apoptosis - physiology Cardiovascular Diseases - drug therapy Cardiovascular Physiological Phenomena - genetics Cardiovascular System - metabolism DNA - metabolism Genomics Humans Kidney - physiology Penile Erection - physiology Reactive Oxygen Species - metabolism Receptors, Androgen - metabolism Testosterone - physiology Testosterone - therapeutic use androgen receptor cardiovascular genomic non-genomic
ISSN:	1470-8736, 1470-8736
On-line prístup:	Zistit podrobnosti o prístupe
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