Children with perinatally acquired HIV exhibit distinct immune responses to 4CMenB vaccine

Children with perinatally acquired HIV (PHIV) have special vaccination needs, as they make suboptimal immune responses. Here, we evaluated safety and immunogenicity of 2 doses of 4-component group B meningococcal vaccine in antiretroviral therapy-treated children with PHIV and healthy controls (HCs)...

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Bibliographic Details
Published in:	JCI insight Vol. 9; no. 10
Main Authors:	Cotugno, Nicola, Neri, Alessia, Sanna, Marco, Santilli, Veronica, Manno, Emma Concetta, Pascucci, Giuseppe Rubens, Morrocchi, Elena, Amodio, Donato, Ruggiero, Alessandra, Ciofi degl Atti, Marta Luisa, Barneschi, Irene, Grappi, Silvia, Cocchi, Ilaria, Giacomet, Vania, Trabattoni, Daria, Olivieri, Giulio, Bernardi, Stefania, O’Connor, Daniel, Montomoli, Emanuele, Pollard, Andrew J., Palma, Paolo
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 22.05.2024 American Society for Clinical investigation
Subjects:	Acquired immune deficiency syndrome Age AIDS AIDS/HIV Antibodies Antibodies, Bacterial - blood Antibodies, Bacterial - immunology Antigens Antiretroviral therapy B-Lymphocytes - immunology Child Child, Preschool Children Female Flow cytometry Gene expression Gene flow Health care HIV HIV Infections - immunology Human immunodeficiency virus Humans Immune response Immunity (Disease) Immunogenicity Immunogenicity, Vaccine Immunoglobulin G Immunoglobulin G - blood Immunoglobulin G - immunology Immunological memory Infectious Disease Transmission, Vertical - prevention & control Lymphocytes B Male Memory cells Meningococcal Infections - immunology Meningococcal Infections - prevention & control Meningococcal Vaccines - administration & dosage Meningococcal Vaccines - immunology Proteins Vaccines AIDS/HIV Adaptive immunity Vaccines Bacterial vaccines
ISSN:	2379-3708, 2379-3708
Online Access:	Get full text
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