Children with perinatally acquired HIV exhibit distinct immune responses to 4CMenB vaccine

Children with perinatally acquired HIV (PHIV) have special vaccination needs, as they make suboptimal immune responses. Here, we evaluated safety and immunogenicity of 2 doses of 4-component group B meningococcal vaccine in antiretroviral therapy-treated children with PHIV and healthy controls (HCs)...

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Vydané v:JCI insight Ročník 9; číslo 10
Hlavní autori: Cotugno, Nicola, Neri, Alessia, Sanna, Marco, Santilli, Veronica, Manno, Emma Concetta, Pascucci, Giuseppe Rubens, Morrocchi, Elena, Amodio, Donato, Ruggiero, Alessandra, Ciofi degl Atti, Marta Luisa, Barneschi, Irene, Grappi, Silvia, Cocchi, Ilaria, Giacomet, Vania, Trabattoni, Daria, Olivieri, Giulio, Bernardi, Stefania, O’Connor, Daniel, Montomoli, Emanuele, Pollard, Andrew J., Palma, Paolo
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States American Society for Clinical Investigation 22.05.2024
American Society for Clinical investigation
Predmet:
Acquired immune deficiency syndrome
Age
AIDS
AIDS/HIV
Antibodies
Antibodies, Bacterial - blood
Antibodies, Bacterial - immunology
Antigens
Antiretroviral therapy
B-Lymphocytes - immunology
Child
Child, Preschool
Children
Female
Flow cytometry
Gene expression
Gene flow
Health care
HIV
HIV Infections - immunology
Human immunodeficiency virus
Humans
Immune response
Immunity (Disease)
Immunogenicity
Immunogenicity, Vaccine
Immunoglobulin G
Immunoglobulin G - blood
Immunoglobulin G - immunology
Immunological memory
Infectious Disease Transmission, Vertical - prevention & control
Lymphocytes B
Male
Memory cells
Meningococcal Infections - immunology
Meningococcal Infections - prevention & control
Meningococcal Vaccines - administration & dosage
Meningococcal Vaccines - immunology
Proteins
Vaccines
AIDS/HIV
Adaptive immunity
Vaccines
Bacterial vaccines
ISSN:2379-3708, 2379-3708
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Shrnutí:Children with perinatally acquired HIV (PHIV) have special vaccination needs, as they make suboptimal immune responses. Here, we evaluated safety and immunogenicity of 2 doses of 4-component group B meningococcal vaccine in antiretroviral therapy-treated children with PHIV and healthy controls (HCs). Assessments included the standard human serum bactericidal antibody (hSBA) assay and measurement of IgG titers against capsular group B Neisseria meningitidis antigens (fHbp, NHBA, NadA). The B cell compartment and vaccine-induced antigen-specific (fHbp+) B cells were investigated by flow cytometry, and gene expression was investigated by multiplexed real-time PCR. A good safety and immunogenicity profile was shown in both groups; however, PHIV demonstrated a reduced immunogenicity compared with HCs. Additionally, PHIV showed a reduced frequency of fHbp+ and an altered B cell subset distribution, with higher fHbp+ frequency in activated memory and tissue-like memory B cells. Gene expression analyses on these cells revealed distinct mechanisms between PHIV and HC seroconverters. Overall, these data suggest that PHIV presents a diverse immune signature following vaccination. The impact of such perturbation on long-term maintenance of vaccine-induced immunity should be further evaluated in vulnerable populations, such as people with PHIV.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:2379-3708
2379-3708
DOI:10.1172/jci.insight.177182