Establishing a Dual Murine Model to Explore the Interactions Between Diabetes and Periodontitis in Mice

This study aimed to develop and validate a dual murine model integrating a high-fat diet (HFD) and a single streptozotocin (STZ) dose to induce diabetes mellitus (DM), alongside periodontitis (Perio) induced by ligature placement and oral inoculation with Porphyromonas gingivalis (P. gingivalis). Th...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 26; no. 12; p. 5611
Main Authors:	Silva, Bárbara R., Hidalgo, Marco A. R., Silva, Renata C. L., de Avila, Erica D., Fuentes, Deivys L. P., Carlos, Iracilda Z., Figueiredo, Ingrid D., Cerri, Estela S., Cerri, Paulo S., Baviera, Amanda M., de Molon, Rafael Scaf, Scarel-Caminaga, Raquel M.
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 11.06.2025 MDPI
Subjects:	Alveolar Bone Loss - pathology Analysis Animals Bacteroidaceae Infections - complications Bacteroidaceae Infections - microbiology Blood Glucose Body fat Carbohydrates Collagen Dextrose Diabetes Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - pathology Diet, High-Fat - adverse effects Disease Models, Animal Enzymes Global health Glucose Gum disease Health aspects Hyperglycemia Inflammation Insulin Insulin Resistance Liu, Timothy Male Metabolism Mice Mice, Inbred C57BL Microbiota Obesity Pathogenesis Periodontitis Periodontitis - complications Periodontitis - etiology Periodontitis - metabolism Periodontitis - microbiology Periodontitis - pathology Porphyromonas gingivalis Public health Streptozocin Virulence Weight control X-Ray Microtomography United States Massachusetts diabetes mellitus mouse model streptozotocin ligature periodontitis
ISSN:	1422-0067, 1661-6596, 1422-0067
Online Access:	Get full text
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