Opioid receptors: drivers to addiction?

Drug addiction is a worldwide societal problem and public health burden, and results from recreational drug use that develops into a complex brain disorder. The opioid system, one of the first discovered neuropeptide systems in the history of neuroscience, is central to addiction. Recently, opioid r...

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Vydáno v:	Nature reviews. Neuroscience Ročník 19; číslo 8; s. 499 - 514
Hlavní autoři:	Darcq, Emmanuel, Kieffer, Brigitte Lina
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 01.08.2018 Nature Publishing Group
Témata:	631/154/436/2387 631/378/1689/5 631/378/1788 631/378/2620/410 Addictions Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Brain - physiopathology Cellular signal transduction Drug abuse Drug addiction Drug use Health aspects Humans Molecular targeted therapy Narcotics Nervous system Neural circuitry Neurobiology Neurons - physiology Neurosciences Opioid receptors (type kappa) Opioid receptors (type mu) Opioids Pain Pain - drug therapy Psychiatric research Public health Receptors Receptors, Opioid, kappa - physiology Receptors, Opioid, mu - physiology Review Article Reward Substance-Related Disorders - etiology Substance-Related Disorders - physiopathology Canada
ISSN:	1471-003X, 1471-0048, 1471-0048, 1469-3178
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Popis
Shrnutí:	Drug addiction is a worldwide societal problem and public health burden, and results from recreational drug use that develops into a complex brain disorder. The opioid system, one of the first discovered neuropeptide systems in the history of neuroscience, is central to addiction. Recently, opioid receptors have been propelled back on stage by the rising opioid epidemics, revolutions in G protein-coupled receptor research and fascinating developments in basic neuroscience. This Review discusses rapidly advancing research into the role of opioid receptors in addiction, and addresses the key questions of whether we can kill pain without addiction using mu-opioid-receptor-targeting opiates, how mu- and kappa-opioid receptors operate within the neurocircuitry of addiction and whether we can bridge human and animal opioid research in the field of drug abuse. The opioid system is central to addiction. Darcq and Kieffer review the role of these receptors in the addiction neurocircuitry, ask whether opioid receptors can be targeted to kill pain without addiction and discuss studies that bridge the translational gap in the field.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Literature Review-3 ObjectType-Review-3 content type line 23
ISSN:	1471-003X 1471-0048 1471-0048 1469-3178
DOI:	10.1038/s41583-018-0028-x