Opioid receptors: drivers to addiction?

Drug addiction is a worldwide societal problem and public health burden, and results from recreational drug use that develops into a complex brain disorder. The opioid system, one of the first discovered neuropeptide systems in the history of neuroscience, is central to addiction. Recently, opioid r...

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Bibliographic Details
Published in:Nature reviews. Neuroscience Vol. 19; no. 8; pp. 499 - 514
Main Authors: Darcq, Emmanuel, Kieffer, Brigitte Lina
Format: Journal Article
Language:English
Published: England Nature Publishing Group 01.08.2018
Subjects:
Addictions
Animals
Brain - physiopathology
Drug abuse
Drug addiction
Drug use
Humans
Narcotics
Nervous system
Neurons - physiology
Neurosciences
Opioid receptors (type kappa)
Opioid receptors (type mu)
Opioids
Pain
Pain - drug therapy
Public health
Receptors, Opioid, kappa - physiology
Receptors, Opioid, mu - physiology
Reward
Substance-Related Disorders - etiology
Substance-Related Disorders - physiopathology
ISSN:1471-003X, 1471-0048, 1471-0048, 1469-3178
Online Access:Get full text
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Summary:Drug addiction is a worldwide societal problem and public health burden, and results from recreational drug use that develops into a complex brain disorder. The opioid system, one of the first discovered neuropeptide systems in the history of neuroscience, is central to addiction. Recently, opioid receptors have been propelled back on stage by the rising opioid epidemics, revolutions in G protein-coupled receptor research and fascinating developments in basic neuroscience. This Review discusses rapidly advancing research into the role of opioid receptors in addiction, and addresses the key questions of whether we can kill pain without addiction using mu-opioid-receptor-targeting opiates, how mu- and kappa-opioid receptors operate within the neurocircuitry of addiction and whether we can bridge human and animal opioid research in the field of drug abuse.
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ISSN:1471-003X
1471-0048
1471-0048
1469-3178
DOI:10.1038/s41583-018-0028-x