Differential roles of two DDX17 isoforms in the formation of membraneless organelles

The RNA helicase, DDX17 is a member of the DEAD-box protein family. DDX17 has two isoforms: p72 and p82. The p82 isoform has additional amino acid sequences called intrinsically disordered regions (IDRs), which are related to the formation of membraneless organelles (MLOs). Here, we reveal that p72...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) Jg. 168; H. 1; S. 33
Hauptverfasser:	Hirai, Yuya, Domae, Eisuke, Yoshikawa, Yoshihiro, Tomonaga, Keizo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 01.07.2020
Schlagworte:	Cell Nucleolus - metabolism Cell Nucleus - metabolism DEAD-box RNA Helicases - metabolism Female HeLa Cells Humans Organelles - metabolism Protein Isoforms RNA - metabolism Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology DDX17 nucleolus stress granules membraneless organelles intrinsically disordered regions
ISSN:	1756-2651, 1756-2651
Online-Zugang:	Weitere Angaben
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