The Activities of Heparan Sulfate and its Analogue Heparin are Dictated by Biosynthesis, Sequence, and Conformation

The glycosaminoglycan heparan sulfate (HS), is expressed on the surface of virtually all mammalian cells and is implicated in many crucial biological activities. The activities of HS and its close structural analogue heparin are mediated through interactions with proteins. However, the relationship...

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Veröffentlicht in:Connective Tissue Research Jg. 49; H. 3-4; S. 140 - 144
Hauptverfasser: Skidmore, Mark A., Guimond, Scott E., Rudd, Tim R., Fernig, David G., Turnbull, Jeremy E., Yates, Edwin A.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Informa UK Ltd 01.01.2008
Taylor & Francis
Schlagworte:
Animals
Carbohydrate Conformation
Carbohydrate Sequence
Cell Line
Cell Proliferation
Conformation
Glycosaminoglycans
Heparan Sulfate
Heparin
Heparin - biosynthesis
Heparin - chemistry
Heparin - metabolism
Heparitin Sulfate - biosynthesis
Heparitin Sulfate - chemistry
Heparitin Sulfate - metabolism
Humans
Sequence
Structure
Structure-Activity Relationship
ISSN:0300-8207, 1607-8438, 1521-0456, 1607-8438
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Zusammenfassung:The glycosaminoglycan heparan sulfate (HS), is expressed on the surface of virtually all mammalian cells and is implicated in many crucial biological activities. The activities of HS and its close structural analogue heparin are mediated through interactions with proteins. However, the relationship between structure and activity is not simple, because the structure and conformation of HS and heparin are complex. This review surveys some of the relevant findings in HS/heparin chemistry, biochemistry, and biology.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0300-8207
1607-8438
1521-0456
1607-8438
DOI:10.1080/03008200802148595