The Activities of Heparan Sulfate and its Analogue Heparin are Dictated by Biosynthesis, Sequence, and Conformation

The glycosaminoglycan heparan sulfate (HS), is expressed on the surface of virtually all mammalian cells and is implicated in many crucial biological activities. The activities of HS and its close structural analogue heparin are mediated through interactions with proteins. However, the relationship...

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Bibliographic Details
Published in:Connective Tissue Research Vol. 49; no. 3-4; pp. 140 - 144
Main Authors: Skidmore, Mark A., Guimond, Scott E., Rudd, Tim R., Fernig, David G., Turnbull, Jeremy E., Yates, Edwin A.
Format: Journal Article
Language:English
Published: England Informa UK Ltd 01.01.2008
Taylor & Francis
Subjects:
Animals
Carbohydrate Conformation
Carbohydrate Sequence
Cell Line
Cell Proliferation
Conformation
Glycosaminoglycans
Heparan Sulfate
Heparin
Heparin - biosynthesis
Heparin - chemistry
Heparin - metabolism
Heparitin Sulfate - biosynthesis
Heparitin Sulfate - chemistry
Heparitin Sulfate - metabolism
Humans
Sequence
Structure
Structure-Activity Relationship
ISSN:0300-8207, 1607-8438, 1521-0456, 1607-8438
Online Access:Get full text
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Summary:The glycosaminoglycan heparan sulfate (HS), is expressed on the surface of virtually all mammalian cells and is implicated in many crucial biological activities. The activities of HS and its close structural analogue heparin are mediated through interactions with proteins. However, the relationship between structure and activity is not simple, because the structure and conformation of HS and heparin are complex. This review surveys some of the relevant findings in HS/heparin chemistry, biochemistry, and biology.
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ISSN:0300-8207
1607-8438
1521-0456
1607-8438
DOI:10.1080/03008200802148595