Chronic 2P-STED imaging reveals high turnover of dendritic spines in the hippocampus in vivo

Rewiring neural circuits by the formation and elimination of synapses is thought to be a key cellular mechanism of learning and memory in the mammalian brain. Dendritic spines are the postsynaptic structural component of excitatory synapses, and their experience-dependent plasticity has been extensi...

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Bibliographic Details
Published in:	eLife Vol. 7
Main Authors:	Pfeiffer, Thomas, Poll, Stefanie, Bancelin, Stephane, Angibaud, Julie, Inavalli, VVG Krishna, Keppler, Kevin, Mittag, Manuel, Fuhrmann, Martin, Nägerl, U Valentin
Format:	Journal Article
Language:	English
Published:	England eLife Sciences Publications, Ltd 22.06.2018 eLife Sciences Publications Ltd
Subjects:	Animals Bacterial Proteins - genetics Bacterial Proteins - metabolism Cerebral Cortex - surgery Dendritic Spines - physiology Dendritic Spines - ultrastructure Female Gene Expression Genes, Reporter Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism hippocampus Hippocampus - anatomy & histology Hippocampus - physiology Hippocampus - ultrastructure Image Processing, Computer-Assisted - statistics & numerical data in vivo imaging learning and memory Luminescent Proteins - genetics Luminescent Proteins - metabolism Male Memory - physiology Mice Mice, Transgenic Microscopy, Fluorescence, Multiphoton - instrumentation Microscopy, Fluorescence, Multiphoton - methods Molecular Imaging - instrumentation Molecular Imaging - methods Nerve Net - anatomy & histology Nerve Net - physiology Nerve Net - ultrastructure Neuronal Plasticity - physiology Neuroscience Pyramidal Cells - physiology Pyramidal Cells - ultrastructure spine plasticity super-resolution microscopy synapses Synapses - physiology Synapses - ultrastructure mouse in vivo imaging synapses hippocampus learning and memory neuroscience spine plasticity super-resolution microscopy
ISSN:	2050-084X, 2050-084X
Online Access:	Get full text
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