Altered decidual and placental catabolism of vitamin D may contribute to the aetiology of spontaneous miscarriage

Vitamin D catabolizing enzymes, along with vitamin D receptor (VDR) and vitamin D binding protein (DBP) are expressed in the decidua and placenta during pregnancy and capable of synthesizing active vitamin D. Vitamin D plays roles in immunoregulation and trophoblast invasion, key features of a succe...

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Bibliographic Details
Published in:	Placenta (Eastbourne) Vol. 92; pp. 1 - 8
Main Authors:	Hou, H., Zhang, J.Y., Chen, D., Deng, F., Morse, A.N., Qiu, X., He, P., Lash, G.E.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01.03.2020
Subjects:	25-Hydroxyvitamin D3 1-alpha-Hydroxylase - metabolism Abortion, Spontaneous - blood Abortion, Spontaneous - enzymology Abortion, Spontaneous - etiology Case-Control Studies Cholestanetriol 26-Monooxygenase - metabolism CYP24A1 CYP27B1 Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Family 2 - metabolism Decidua - enzymology Female Humans Maternal-fetal interface Pregnancy Receptors, Calcitriol - metabolism Spontaneous miscarriage Vitamin D Vitamin D - metabolism Vitamin D-Binding Protein - metabolism Vitamin D3 24-Hydroxylase - metabolism CYP27B1 Maternal-fetal interface CYP24A1 Vitamin D Spontaneous miscarriage
ISSN:	0143-4004, 1532-3102, 1532-3102
Online Access:	Get full text
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