Optimizing ex vivo penetration tests via quantitative confocal Raman spectroscopy: Impact of incubation time, skin hydration, surfactant treatment and UVA irradiation on caffeine distribution

[Display omitted] Ex vivo penetration tests are important tools in cosmetic and pharmaceutical research. However, variability of experimental setups is challenging when reviewing literature. Different skin models, pre-treatments and experimental parameters render comparison difficult. Thus, our aim...

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Veröffentlicht in:	International journal of pharmaceutics Jg. 667; H. Pt B; S. 124932
Hauptverfasser:	Steiner, Katja, Hübel, Pia, Srndic, Azra, Klang, Victoria
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 25.12.2024
Schlagworte:	Animals Caffeine Caffeine - pharmacokinetics Confocal Raman spectroscopy Humans Penetration Porcine ear skin quantitative CRS Skin - metabolism Skin - radiation effects Skin Absorption Sodium Dodecyl Sulfate - analogs & derivatives Sodium Dodecyl Sulfate - chemistry Spectrum Analysis, Raman - methods Surface-Active Agents - chemistry Surfactant Time Factors Ultraviolet Rays UVA Water - chemistry UVA SLES UV CRS quantitative CRS Surfactant SC Porcine ear skin Penetration PC PE NE Confocal Raman spectroscopy LPC PS80 Caffeine HLB MCT
ISSN:	0378-5173, 1873-3476, 1873-3476
Online-Zugang:	Volltext
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