A case of catamenial erythema multiforme major successfully treated with goserelin

We report a case of catamenial erythema multiforme major in a 46-year-old female. She was treated successfully with goserelin, a GnRH agonist, until the expected age of menopause; however, its therapeutic effects persisted for longer than expected, possibly due to accumulation in adipose tissue. A g...

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Bibliographic Details
Published in:Endocrinology, diabetes & metabolism case reports Vol. 2023; no. 4; pp. 1 - 3
Main Authors: Tyack, Lauren T, Stuckey, Bronwyn G A, Walsh, John P
Format: Journal Article
Language:English
Published: England Bioscientifica Ltd 01.10.2023
Bioscientifica
Subjects:
Adult
Australia
Female
Gynaecological Endocrinology
New Disease or Syndrome: Presentations/Diagnosis/Management
Ovaries
White
ISSN:2052-0573, 2052-0573
Online Access:Get full text
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Summary:We report a case of catamenial erythema multiforme major in a 46-year-old female. She was treated successfully with goserelin, a GnRH agonist, until the expected age of menopause; however, its therapeutic effects persisted for longer than expected, possibly due to accumulation in adipose tissue. A group of menstrual cycle-related dermatoses and hypersensitivity syndromes exist but are rarely reported in the literature. A history of recurrent cutaneous eruptions in premenopausal females should be considered in the context of the menstrual cycle. The diagnosis of menstrual cycle-related dermatoses is largely clinical, although provocation testing can assist. Treatment options are broad and are aimed at reducing the immune response and/or suppressing ovulation. Goserelin may accumulate and have a gonadotrophin-suppressing effect for longer than expected.
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ISSN:2052-0573
2052-0573
DOI:10.1530/EDM-23-0030