A simple and easy non‐derivatization gas chromatography‐mass spectrometry method for simultaneous quantification of valproic acid, gabapentin, pregabalin, and vigabatrin in human plasma

Immunoassays are currently not available in commercial kits for the quantification of valproic acid, vigabatrin, pregabalin, and gabapentin, which also cannot suffer the limitations of interferences of substances with similar structures. Chromatography is a good alternative to immunoassay. In this s...

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Bibliographic Details
Published in:	Journal of separation science Vol. 46; no. 2; pp. e2200622 - n/a
Main Authors:	Jin, Peng, You, Yu‐xin, Zhao, Lin‐lin, Zhao, Yan‐lin, Zheng, Xiao‐xiao, Du, Yan, Tang, Dao‐quan
Format:	Journal Article
Language:	English
Published:	Germany Wiley Subscription Services, Inc 01.01.2023
Subjects:	Acidification Amines - analysis Anticonvulsants antiepileptic drugs Benzoic acid Blood plasma chemical species Chromatography Correlation coefficients Cyclohexanecarboxylic Acids - analysis Cyclohexanecarboxylic Acids - chemistry Epilepsy Gabapentin - analysis gamma-Aminobutyric Acid Gas chromatography gas chromatography-mass spectrometry Gas Chromatography-Mass Spectrometry - methods human plasma Humans Hydrochloric acid Immunoassay immunoassays Linearity Mass spectrometry non‐derivatization Plasma Pregabalin - analysis Scientific imaging separation Spectroscopy standard deviation therapeutic drug monitoring therapeutics valproic acid Valproic Acid - analysis Vigabatrin - analysis antiepileptic drugs gas chromatography-mass spectrometry non-derivatization human plasma therapeutic drug monitoring
ISSN:	1615-9306, 1615-9314, 1615-9314
Online Access:	Get full text
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