The Effect of Doxycycline Hyclate, Chlorhexidine Gluconate, and Minocycline Hydrochloride on Osteoblastic Proliferation and Differentiation In Vitro

Background: The purpose of this study was to determine the effect of the active substance of three types of local delivery systems, doxycycline hyclate 10% (DOXY), chlorhexidine gluconate, 2.5 mg (CHX), and minocycline hydrochloride, 1 mg (MINO), on osteoblastic cell proliferation and differentiatio...

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Bibliographic Details
Published in:	Journal of periodontology (1970) Vol. 80; no. 6; pp. 999 - 1005
Main Authors:	Almazin, Salah M., Dziak, Rosemary, Andreana, Sebastiano, Ciancio, Sebastian G.
Format:	Journal Article
Language:	English
Published:	Chicago, IL American Academy of Periodontology 01.06.2009
Subjects:	Alkaline Phosphatase - analysis Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - toxicity Anti-Infective Agents, Local - pharmacology Anti-Infective Agents, Local - toxicity Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antiseptics Biological and medical sciences Biomarkers - analysis Cell Adhesion - drug effects Cell Differentiation - drug effects Cell Nucleus - drug effects Cell Proliferation - drug effects Cell Shape - drug effects Cell Survival - drug effects Cells, Cultured Chlorhexidine - analogs & derivatives Chlorhexidine - pharmacology Chlorhexidine - toxicity Coloring Agents Doxycycline - analogs & derivatives Doxycycline - pharmacology Doxycycline - toxicity Drug Carriers Drugs Female Gels Humans Male Medical sciences Microscopy, Electron, Scanning Microspheres Middle Aged Minocycline - pharmacology Minocycline - toxicity osteoblasts Osteoblasts - drug effects Otorhinolaryngology. Stomatology periodontium Pharmacology. Drug treatments Pseudopodia - drug effects Tetrazolium Salts Thiazoles Trypan Blue Drugs Dentistry In vitro Antibiotic Periodontal ligament periodontium Antiseptic Doxycycline Hyclate Minocycline Osteoblast Chlorhexidine osteoblasts Antibacterial agent Differentiation Disinfecting agent
ISSN:	0022-3492, 1943-3670
Online Access:	Get full text
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