Treatment Outcomes in Multidrug-Resistant Tuberculosis

Multidrug-resistant tuberculosis is a major global challenge. This report examines the definition of treatment success and its effect on determining cure. To the Editor: Despite lengthy treatment with costly second-line drug regimens, curing multidrug-resistant (MDR) tuberculosis (bacillary resistan...

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Veröffentlicht in:The New England journal of medicine Jg. 375; H. 11; S. 1103 - 1105
Hauptverfasser: Günther, Gunar, Lange, Christoph, Alexandru, Sofia, Altet, Neus, Avsar, Korkut, Bang, Didi, Barbuta, Raisa, Bothamley, Graham, Ciobanu, Ana, Crudu, Valeriu, Danilovits, Manfred, Dedicoat, Martin, Duarte, Raquel, Gualano, Gina, Kunst, Heinke, de Lange, Wiel, Leimane, Vaira, Magis-Escurra, Cecile, McLaughlin, Anne-Marie, Muylle, Inge, Polcová, Veronika, Popa, Christina, Rumetshofer, Rudolf, Skrahina, Alena, Solodovnikova, Varvara, Spinu, Victor, Tiberi, Simon, Viiklepp, Piret, van Leth, Frank
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Massachusetts Medical Society 15.09.2016
Schlagworte:
Clinical outcomes
Humans
Multidrug resistance
Mycobacterium tuberculosis - isolation & purification
Outcome Assessment (Health Care) - methods
Treatment Outcome
Tuberculosis
Tuberculosis, Multidrug-Resistant - drug therapy
World Health Organization
ISSN:0028-4793, 1533-4406, 1533-4406
Online-Zugang:Volltext
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Zusammenfassung:Multidrug-resistant tuberculosis is a major global challenge. This report examines the definition of treatment success and its effect on determining cure. To the Editor: Despite lengthy treatment with costly second-line drug regimens, curing multidrug-resistant (MDR) tuberculosis (bacillary resistance to at least isoniazid and rifampin) remains a challenge. 1 The World Health Organization (WHO) defines “cure” as “treatment completion” with at least three negative cultures after the intensive phase of therapy in the absence of “treatment failure.” The definition of “treatment failure” requires early termination of treatment or the need for permanent regimen change of at least two antituberculosis drugs. “Treatment success” is defined as the sum of cure and treatment completion. 2 We evaluated treatment outcomes according to WHO definitions in the TBNET . . .
Bibliographie:SourceType-Scholarly Journals-1
ObjectType-Correspondence-2
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ObjectType-Letter to the Editor-1
ObjectType-Article-2
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMc1603274