Treatment Outcomes in Multidrug-Resistant Tuberculosis

Multidrug-resistant tuberculosis is a major global challenge. This report examines the definition of treatment success and its effect on determining cure. To the Editor: Despite lengthy treatment with costly second-line drug regimens, curing multidrug-resistant (MDR) tuberculosis (bacillary resistan...

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Vydáno v:	The New England journal of medicine Ročník 375; číslo 11; s. 1103 - 1105
Hlavní autoři:	Günther, Gunar, Lange, Christoph, Alexandru, Sofia, Altet, Neus, Avsar, Korkut, Bang, Didi, Barbuta, Raisa, Bothamley, Graham, Ciobanu, Ana, Crudu, Valeriu, Danilovits, Manfred, Dedicoat, Martin, Duarte, Raquel, Gualano, Gina, Kunst, Heinke, de Lange, Wiel, Leimane, Vaira, Magis-Escurra, Cecile, McLaughlin, Anne-Marie, Muylle, Inge, Polcová, Veronika, Popa, Christina, Rumetshofer, Rudolf, Skrahina, Alena, Solodovnikova, Varvara, Spinu, Victor, Tiberi, Simon, Viiklepp, Piret, van Leth, Frank
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Massachusetts Medical Society 15.09.2016
Témata:	Clinical outcomes Humans Multidrug resistance Mycobacterium tuberculosis - isolation & purification Outcome Assessment (Health Care) - methods Treatment Outcome Tuberculosis Tuberculosis, Multidrug-Resistant - drug therapy World Health Organization
ISSN:	0028-4793, 1533-4406, 1533-4406
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Shrnutí:	Multidrug-resistant tuberculosis is a major global challenge. This report examines the definition of treatment success and its effect on determining cure. To the Editor: Despite lengthy treatment with costly second-line drug regimens, curing multidrug-resistant (MDR) tuberculosis (bacillary resistance to at least isoniazid and rifampin) remains a challenge. 1 The World Health Organization (WHO) defines “cure” as “treatment completion” with at least three negative cultures after the intensive phase of therapy in the absence of “treatment failure.” The definition of “treatment failure” requires early termination of treatment or the need for permanent regimen change of at least two antituberculosis drugs. “Treatment success” is defined as the sum of cure and treatment completion. 2 We evaluated treatment outcomes according to WHO definitions in the TBNET . . .
Bibliografie:	SourceType-Scholarly Journals-1 ObjectType-Correspondence-2 content type line 14 ObjectType-Letter to the Editor-1 ObjectType-Article-2 ObjectType-Correspondence-1 content type line 23
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMc1603274