Pharmacological Management of Insomnia in Parkinson's Disease

Sleep dysfunction can affect almost 90% of Parkinson's disease (PD) patients and insomnia related to fragmented sleep is common. Satisfactory management remains an unmet need although dopaminergic non-oral treatments utilising a continuous drug delivery strategy appears to help sleep maintenanc...

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Bibliographic Details
Published in:	Sleep medicine clinics Vol. 20; no. 3; p. 389
Main Authors:	Popławska-Domaszewicz, Karolina, Metta, Vinod, Chen, Rosabel, Falup-Pecurariu, Cristian, Wu, Kit, Chaudhuri, K Ray
Format:	Journal Article
Language:	English
Published:	United States 01.09.2025
Subjects:	Dopamine Agonists - therapeutic use Humans Hypnotics and Sedatives - therapeutic use Parkinson Disease - complications Parkinson Disease - drug therapy Sleep Initiation and Maintenance Disorders - drug therapy Sleep Initiation and Maintenance Disorders - etiology Maintenance insomnia Sleep Stepped care Parkinson’s disease Onset insomnia
ISSN:	1556-4088
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Summary:	Sleep dysfunction can affect almost 90% of Parkinson's disease (PD) patients and insomnia related to fragmented sleep is common. Satisfactory management remains an unmet need although dopaminergic non-oral treatments utilising a continuous drug delivery strategy appears to help sleep maintenance insomnia. Transdermal therapy with rotigotine or subcutaneous apomorphine infusion is effective while recent data show considerable efficacy of intrajejunal or subcutaneous levodopa infusion on alleviation of insomnia in PD. Pharmacologic management of sleep onset insomnia remains suboptimal and options range from cautious use of sedatives and hypnotics to management of comorbid factors, such as psychosis and depression.
ISSN:	1556-4088
DOI:	10.1016/j.jsmc.2025.06.004