Pharmacological Management of Insomnia in Parkinson's Disease

Sleep dysfunction can affect almost 90% of Parkinson's disease (PD) patients and insomnia related to fragmented sleep is common. Satisfactory management remains an unmet need although dopaminergic non-oral treatments utilising a continuous drug delivery strategy appears to help sleep maintenanc...

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Veröffentlicht in:	Sleep medicine clinics Jg. 20; H. 3; S. 389
Hauptverfasser:	Popławska-Domaszewicz, Karolina, Metta, Vinod, Chen, Rosabel, Falup-Pecurariu, Cristian, Wu, Kit, Chaudhuri, K Ray
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.09.2025
Schlagworte:	Dopamine Agonists - therapeutic use Humans Hypnotics and Sedatives - therapeutic use Parkinson Disease - complications Parkinson Disease - drug therapy Sleep Initiation and Maintenance Disorders - drug therapy Sleep Initiation and Maintenance Disorders - etiology Maintenance insomnia Sleep Stepped care Parkinson’s disease Onset insomnia
ISSN:	1556-4088
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Beschreibung
Zusammenfassung:	Sleep dysfunction can affect almost 90% of Parkinson's disease (PD) patients and insomnia related to fragmented sleep is common. Satisfactory management remains an unmet need although dopaminergic non-oral treatments utilising a continuous drug delivery strategy appears to help sleep maintenance insomnia. Transdermal therapy with rotigotine or subcutaneous apomorphine infusion is effective while recent data show considerable efficacy of intrajejunal or subcutaneous levodopa infusion on alleviation of insomnia in PD. Pharmacologic management of sleep onset insomnia remains suboptimal and options range from cautious use of sedatives and hypnotics to management of comorbid factors, such as psychosis and depression.
ISSN:	1556-4088
DOI:	10.1016/j.jsmc.2025.06.004