Tubular Apocrine Adenoma with Uncertain Malignant Findings: Report of a Case and Review of the Literature

Introduction: Tubular apocrine adenoma (TAA) is a rare sweat gland tumor, usually presenting as a well-defined, red to brown nodule on the scalp. Generally, TAA is considered as benign tumor; however, it may be difficult to differentiate TAA from metastatic or primary carcinoma. Case Presentation: A...

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Published in:Case reports in dermatology Vol. 17; no. 1; pp. 240 - 245
Main Authors: Tokuchi, Keiko, Yanagi, Teruki, Maeda, Takuya, Nakazato, Shinichi, Miyamoto, Kodai, Tomaru, Utano, Anan, Takashi, Ujiie, Hideyuki
Format: Journal Article
Language:English
Published: Switzerland S. Karger AG 10.04.2025
Subjects:
Single Case
Appendage tumors
Sweat gland tumor
Malignant findings
Tubular apocrine adenoma
Apocrine carcinoma
ISSN:1662-6567, 1662-6567
Online Access:Get full text
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Summary:Introduction: Tubular apocrine adenoma (TAA) is a rare sweat gland tumor, usually presenting as a well-defined, red to brown nodule on the scalp. Generally, TAA is considered as benign tumor; however, it may be difficult to differentiate TAA from metastatic or primary carcinoma. Case Presentation: A woman in her 90s presented with a pale red nodule on her right posterior auricle for 3 years. Histology showed several tubular structures contained two layers in the dermis. These showed decapitation secretion. At the periphery of the lesion, squamoid tumor cells formed nest-like patterns. Some squamoid tumor cells exhibited multinucleation. Based on the histopathological, immunohistochemical, and molecular biology findings, the tumor was diagnosed as TAA with undefined malignant changes. Conclusion: TAA is a rare sweat gland neoplasm. Although TAA is generally benign, it can exhibit aggressive features, making thorough pathological evaluation crucial to rule out malignancy.
Bibliography:ObjectType-Case Study-2
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ISSN:1662-6567
1662-6567
DOI:10.1159/000545712