Novel mutation of the cyclin-dependent kinase 4 gene in a Chinese patient with intimal sarcoma of the pulmonary artery

The long arm of human chromosome 12 contains a region that has been found to be amplified in a number of different tumors, including osteosarcomas and soft tissue sarcomas. There are more than 5 genes located in this area such as CDK2, CDK4, WNT1, MDM2 and WNTIOb. CDK4 gene consists of eight exons,...

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Vydané v:	Chinese medical journal Ročník 122; číslo 9; s. 1107 - 1109
Hlavní autori:	Gao, Feng, Liu, Qi-cai, Wang, Mi, Wang, Zhi-qiang, Huang, Yi, Zhou, Xiao-hui, Zhang, Sheng
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	China Department of Gene Diagnosis First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China%Department of Neurology First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China%Department of Chemistry First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China%Department of Laboratory Medicine First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China 05.05.2009 Department of Pathology First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China%Department of Laboratory Medicine First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China
Predmet:	12号染色体 CDK4基因 Cyclin-Dependent Kinase 4 - genetics Exons - genetics Humans Magnetic Resonance Imaging Mutation - genetics Polymerase Chain Reaction Polymorphism, Genetic - genetics Pulmonary Artery - metabolism Pulmonary Artery - pathology Sarcoma - genetics 第8外显子细胞周期蛋白依赖性激酶4 肺动脉软组织肉瘤 CDK4 gene pulmonary artery clinical character intimal sarcoma
ISSN:	0366-6999, 2542-5641, 2542-5641
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Popis
Shrnutí:	The long arm of human chromosome 12 contains a region that has been found to be amplified in a number of different tumors, including osteosarcomas and soft tissue sarcomas. There are more than 5 genes located in this area such as CDK2, CDK4, WNT1, MDM2 and WNTIOb. CDK4 gene consists of eight exons, of which the start codon is located in the beginning of exon 2 and the stop codon in the a member of the Ser-Thr catalytic domain extends beginning of exon 8. CDK4 is protein kinase family and its from amino acid 6 to 295.
Bibliografia:	CDK4 gene intimal sarcoma, pulmonary artery 11-2154/R CDK4 gene; intimal sarcoma, pulmonary artery; clinical character clinical character R781.5 R739.410.2 ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0366-6999 2542-5641 2542-5641
DOI:	10.3760/cma.j.issn.0366-6999.2009.09.018