Novel mutation of the cyclin-dependent kinase 4 gene in a Chinese patient with intimal sarcoma of the pulmonary artery

The long arm of human chromosome 12 contains a region that has been found to be amplified in a number of different tumors, including osteosarcomas and soft tissue sarcomas. There are more than 5 genes located in this area such as CDK2, CDK4, WNT1, MDM2 and WNTIOb. CDK4 gene consists of eight exons,...

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Published in:Chinese medical journal Vol. 122; no. 9; pp. 1107 - 1109
Main Authors: Gao, Feng, Liu, Qi-cai, Wang, Mi, Wang, Zhi-qiang, Huang, Yi, Zhou, Xiao-hui, Zhang, Sheng
Format: Journal Article
Language:English
Published: China Department of Gene Diagnosis First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China%Department of Neurology First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China%Department of Chemistry First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China%Department of Laboratory Medicine First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China 05.05.2009
Department of Pathology First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China%Department of Laboratory Medicine First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China
Subjects:
12号染色体
CDK4基因
Cyclin-Dependent Kinase 4 - genetics
Exons - genetics
Humans
Magnetic Resonance Imaging
Mutation - genetics
Polymerase Chain Reaction
Polymorphism, Genetic - genetics
Pulmonary Artery - metabolism
Pulmonary Artery - pathology
Sarcoma - genetics
第8外显子
细胞周期蛋白依赖性激酶4
肺动脉
软组织肉瘤
CDK4 gene
pulmonary artery
clinical character
intimal sarcoma
ISSN:0366-6999, 2542-5641, 2542-5641
Online Access:Get full text
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Summary:The long arm of human chromosome 12 contains a region that has been found to be amplified in a number of different tumors, including osteosarcomas and soft tissue sarcomas. There are more than 5 genes located in this area such as CDK2, CDK4, WNT1, MDM2 and WNTIOb. CDK4 gene consists of eight exons, of which the start codon is located in the beginning of exon 2 and the stop codon in the a member of the Ser-Thr catalytic domain extends beginning of exon 8. CDK4 is protein kinase family and its from amino acid 6 to 295.
Bibliography:CDK4 gene
intimal sarcoma, pulmonary artery
11-2154/R
CDK4 gene; intimal sarcoma, pulmonary artery; clinical character
clinical character
R781.5
R739.410.2
ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:0366-6999
2542-5641
2542-5641
DOI:10.3760/cma.j.issn.0366-6999.2009.09.018