Transcriptional state and function of CD8 + memory T cells is linked to past proliferation

A new genetic ‘recorder’ of long-term cell proliferation revealed substantial heterogeneity in the division history of central memory CD8+ T cells. Importantly, the extent of past proliferation was related to distinct transcriptional features and re-expansion potential, highlighting an unappreciated...

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Bibliographic Details
Published in:Nature immunology Vol. 23; no. 5; pp. 658 - 659
Format: Journal Article
Language:English
Published: United States Nature Publishing Group 01.05.2022
Subjects:
CD8 antigen
Cell cycle
Cell growth
Cell proliferation
Division of labor
Genetic engineering
Heterogeneity
Immunological memory
Immunology
Infections
Lymphocytes
Lymphocytes T
Memory cells
Population
Stem cells
ISSN:1529-2908, 1529-2916, 1529-2916
Online Access:Get full text
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Summary:A new genetic ‘recorder’ of long-term cell proliferation revealed substantial heterogeneity in the division history of central memory CD8+ T cells. Importantly, the extent of past proliferation was related to distinct transcriptional features and re-expansion potential, highlighting an unappreciated division of labor within the central memory T cell pool.
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ISSN:1529-2908
1529-2916
1529-2916
DOI:10.1038/s41590-022-01169-3